ReviewInternal and emergency medicine2010
Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged.
Review in Internal and emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study.Perioperative medicine (London, England) · 2026Article
- A novel non-invasive nomogram for predicting advanced liver fibrosis in autoimmune hepatitis.Scientific reports · 2026Article
- A novel web-based online nomogram to predict advanced liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.Journal of translational autoimmunity · 2023Article
- Disseminated Intravascular Coagulation in Sepsis and Associated Factors.Journal of clinical medicine · 2022Article
- Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.Cureus · 2022Review
- Prognostic Analysis of Liver Cirrhosis Patients with Cerebral Infarction and/or Gastrointestinal Hemorrhage: A Retrospective Cohort Study.Computational and mathematical methods in medicine · 2022Article
- Features of Blood Clotting on Thromboelastography in Hospitalized Patients With Cirrhosis.The American journal of medicine · 2020Article
- Child-Pugh B or C Cirrhosis Increases the Risk for Bleeding Following Colonoscopic Polypectomy.Gut and liver · 2020Article
- [Advances in the study of gastroesophageal varices with portal vein thrombosis in liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019Review
- Clinical Value of Trans-parenchymal Compressing Suture to Decrease the Cutting Surface Related Complications after Non-anatomical Liver Resection.Current medical science · 2019Article
- The Misunderstood Coagulopathy of Liver Disease: A Review for the Acute Setting.The western journal of emergency medicine · 2018Review
- Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.The Journal of surgical research · 2017Article
- Coagulopathy in liver disease: Lack of an assessment tool.World journal of gastroenterology · 2015Review
- Spontaneous bleeding or thrombosis in cirrhosis: What should be feared the most?World journal of hepatology · 2015Article
- Venous thromboembolism in patients with liver diseases.Internal and emergency medicine · 2015Article
- Does decreased fibrinolysis have a role to play in the development of non-neoplastic portal vein thrombosis in patients with hepatic cirrhosis?Internal and emergency medicine · 2014Article
- Low molecular weight heparin in portal vein thrombosis of cirrhotic patients: only therapeutic purposes?TheScientificWorldJournal · 2014Article
- The role of eltrombopag in the management of hepatitis C virus-related thrombocytopenia.Hepatic medicine : evidence and research · 2013Review
- Percutaneous ultrasonographically guided liver punctures: an analysis of 1961 patients over a period of ten years.BMC gastroenterology · 2012Article
- Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma.Internal and emergency medicine · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic liver disease is characterized by a global hemostatic defect including platelet-vessel wall interaction (primary hemostasis), coagulation and fibrinolysis that may cause abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with the timing and incidence of actual bleeding. In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.