ReviewPediatric nephrology (Berlin, Germany)2009
Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review.
Review in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Transient secondary pseudo-hypoaldosteronism in infants with urinary tract infections: systematic literature review.European journal of pediatrics · 2024Pooled it
- Congenital aldosterone deficiency and its resistance.Endocrine journal · 2026Review
- An Infant With Hyponatremia, Hyperkalemia, and Faltering Growth: A Case Report.Case reports in endocrinology · 2026Article
- A Novel SCNN1B Mutation in a Neonate With Systemic Pseudohypoaldosteronism Type 1: Case Report.Clinical case reports · 2026Article
- Clinical and Biochemical Characteristics of Pseudohypoaldosteronism Type 1 with and Without Genetic Mutations: A Literature Review.Journal of clinical medicine · 2025Article
- Prevalence of and factors associated with Na + /K + imbalances in a population of children hospitalized with febrile urinary tract infection.European journal of pediatrics · 2024Article
- A case of secondary pseudohypoaldosteronism that presented as poor weight gain.Clinical case reports · 2024Article
- Article
- Hyponatremia in babies: a 11-year single-center study.Frontiers in pediatrics · 2024Article
- Hyponatremia and other potential markers of ultrasound abnormalities after a first febrile urinary tract infection in children.European journal of pediatrics · 2023Article
- Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study.Journal of clinical medicine · 2023Article
- Article
- Analysis of patients presenting with serum electrolyte imbalance in terms of the differential diagnosis of pseudohypoaldosteronism.Northern clinics of Istanbul · 2023Article
- Case report: Life threatening hyponatremia in infants with urinary tract infections: two cases of type III pseudohypoaldosteronism and review of the literature.Frontiers in pediatrics · 2023Article
- TRANSIENT PSEUDOHYPOALDOSTERONISM SECONDARY TO URINARY TRACT INFECTION IN A MALE INFANT WITH UNILATERAL HYDRONEPHROSIS DUE TO PRIMARY OBSTRUCTIVE MEGAURETER: A CASE REPORT.Acta clinica Croatica · 2022Article
- Challenges of Diagnosing Pseudohypoaldosteronism (PHA) in an Infant.Case reports in endocrinology · 2022Article
- Sexual Dimorphism of Corticosteroid Signaling during Kidney Development.International journal of molecular sciences · 2021Review
- Article
- Hyponatremia in childhood urinary tract infection.European journal of pediatrics · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eight boys aged 2-12 weeks with urinary tract malformations (UTMs) exhibited features of transient type 1 pseudo-hypoaldosteronism (TPHA1) in the course of urinary tract infection (UTI). Hyponatremia (120.9+/-5.8 mmol/l), hyperkalemia (6.9+/-0.9 mmol/l), metabolic acidosis (plasma bicarbonate 11+/-1.4 mmol/l), and a rise in serum creatinine levels (145+/-101 micromol/l) were associated with high urinary sodium (Na) and low potassium (K) excretion. Tubular resistance to aldosterone was indicated by high plasma aldosterone concentrations (170.4+/-100.5 ng/dl), high levels of the plasma aldosterone to potassium ratio (25.2+/-15.6), and diminished urinary K/Na values (0.31+/-0.19). With appropriate therapy, serum electrolytes, creatinine, and acid-base balance normalized within 2 weeks. A Medline search revealed another 85 cases of TPHA1 reported to date. All of the 93 patients were less than 7 months of age and 90% were less than 3 months of age, 90.3% suffered from UTM, with associated UTI in 89% of them, 11% had UTMin the absence of UTI, and 9.7% showed isolated UTI. These findings indicate that early infancy is the main contributing factor for TPHA1 to occur and that UTI and UTMare additional factors, with at least one being required for its development.
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