ArticleClinical ophthalmology (Auckland, N.Z.)2009
Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin) for AMD followed by controlateral sympathetic ophthalmia.
Article in Clinical ophthalmology (Auckland, N.Z.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Anti-VEGF Drugs in Age-Related Macular Degeneration: A Focus on Dosing Regimen-Related Safety and Efficacy.Drugs & aging · 2023Review
- An atypical presentation of sympathetic ophthalmia following chemical ocular burns.Journal of ophthalmic inflammation and infection · 2023Article
- Sympathetic Ophthalmia: Where Do We Currently Stand on Treatment Strategies?Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Negative regulators of angiogenesis: important targets for treatment of exudative AMD.Clinical science (London, England : 1979) · 2017Review
- ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.Neuro-oncology · 2017Article
- Suppression of Human Tenon Fibroblast Cell Proliferation by Lentivirus-Mediated VEGF Small Hairpin RNA.Journal of ophthalmology · 2017Article
- Pituitary Apoplexy After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitor: A Novel Complication.Journal of neurological surgery reports · 2015Article
- Comparative safety and tolerability of anti-VEGF therapy in age-related macular degeneration.Drug safety · 2015Review
- Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature.Eye (London, England) · 2013Review
- Visual loss from hyphema following intravitreal bevacizumab.BMJ case reports · 2010Article
- Suprachoroidal hemorrhage postintracameral bevacizumab injection: An unusual case report and review of literature.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin((R))), in a patient with exudative age-related macular degeneration (AMD). PATIENTS AND
methodCase report.
resultsTen days after intravitreal injection of 1.25 mg Avastin((R)), the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.
conclusionSerious ocular complications after intravitreal of Avastin((R)) can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.
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