ArticlePLoS genetics2009
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- Replication and fine mapping of asthma-associated loci in individuals of African ancestry.Human genetics · 2013Pooled it
- Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.Nature genetics · 2011Pooled it
- Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.PLoS genetics · 2011Pooled it
- Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study.Respiratory research · 2013Trial
- Identification of ATPAF1 as a novel candidate gene for asthma in children.The Journal of allergy and clinical immunology · 2011Trial
- Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium.Carcinogenesis · 2025Article
- Omics approaches in asthma research: Challenges and opportunities.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression.PloS one · 2022Article
- BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.American journal of respiratory and critical care medicine · 2019Article
- Reconstructing recent population history while mapping rare variants using haplotypes.Scientific reports · 2019Article
- Lessons Learned From GWAS of Asthma.Allergy, asthma & immunology research · 2019Review
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- Lessons from ten years of genome-wide association studies of asthma.Clinical & translational immunology · 2017Review
- Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.American journal of respiratory and critical care medicine · 2017Article
- Transferability of genome-wide associated loci for asthma in African Americans.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
- What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.Current allergy and asthma reports · 2016Review
- Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies.American journal of respiratory and critical care medicine · 2016Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedWillis-Owens, Saffron A G [corrected to Willis-Owen, Saffron A G]
Authors and funding
19 authors at 12 institutions in 3 countries.
Funding
Abstract
Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in 492 Mexican children with asthma, predominantly atopic by skin prick test, and their parents using the Illumina HumanHap 550 K BeadChip to identify novel genetic variation for childhood asthma. The 520,767 autosomal single nucleotide polymorphisms (SNPs) passing quality control were tested for association with childhood asthma using log-linear regression with a log-additive risk model. Eleven of the most significantly associated GWAS SNPs were tested for replication in an independent study of 177 Mexican case-parent trios with childhood-onset asthma and atopy using log-linear analysis. The chromosome 9q21.31 SNP rs2378383 (p = 7.10x10(-6) in the GWAS), located upstream of transducin-like enhancer of split 4 (TLE4), gave a p-value of 0.03 and the same direction and magnitude of association in the replication study (combined p = 6.79x10(-7)). Ancestry analysis on chromosome 9q supported an inverse association between the rs2378383 minor allele (G) and childhood asthma. This work identifies chromosome 9q21.31 as a novel susceptibility locus for childhood asthma in Mexicans. Further, analysis of genome-wide expression data in 51 human tissues from the Novartis Research Foundation showed that median GWAS significance levels for SNPs in genes expressed in the lung differed most significantly from genes not expressed in the lung when compared to 50 other tissues, supporting the biological plausibility of our overall GWAS findings and the multigenic etiology of childhood asthma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.