ArticleThe EMBO journal2009
Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Unraveling the mechanisms and evolution of a two-domain module in IQGAP proteins for controlling eukaryotic cytokinesis.Cell reports · 2023Article
- Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II.Life science alliance · 2023Article
- The Functionally Important N-Terminal Half of Fission Yeast Mid1p Anillin Is Intrinsically Disordered and Undergoes Phase Separation.Biochemistry · 2019Article
- Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.BMC molecular and cell biology · 2019Article
- Mechanics and regulation of cytokinesis in budding yeast.Seminars in cell & developmental biology · 2017Review
- Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner.Scientific reports · 2015Article
- IQGAP1 is associated with nuclear envelope reformation and completion of abscission.Cell cycle (Georgetown, Tex.) · 2015Article
- Evolution and cell physiology. 3. Using Dictyostelium discoideum to investigate mechanisms of epithelial polarity.American journal of physiology. Cell physiology · 2013Review
- SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.Genes & development · 2013Article
- In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.Nature cell biology · 2013Article
- Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.Molecular biology of the cell · 2013Article
- Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.PloS one · 2013Article
- Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.PloS one · 2013Article
- Myosin Vs organize actin cables in fission yeast.Molecular biology of the cell · 2012Article
- Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast.The Journal of cell biology · 2012Article
- Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.Molecular biology of the cell · 2012Article
- Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.Developmental cell · 2012Article
- IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells.International journal of cell biology · 2012Article
- The functionally distinct fission yeast formins have specific actin-assembly properties.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contractile ring (CR) consists of bundled actin filaments and myosin II; however, the actin-bundling factor remains elusive. We show that the fission yeast Schizosaccharomyces pombe IQGAP Rng2 is involved in the generation of CR F-actin and required for its arrangement into a ring. An N-terminal fragment of Rng2 is necessary for the function of Rng2 and is localized to CR F-actin. In vitro the fragment promotes actin polymerization and forms linear arrays of F-actin, which are resistant to the depolymerization induced by the actin-depolymerizing factor Adf1. Our findings indicate that Rng2 is involved in the generation of CR F-actin and simultaneously bundles the filaments and regulates its dynamics by counteracting the effects of Adf1, thus enabling the reconstruction of CR F-actin bundles, which provides an insight into the physical properties of the building blocks that comprise the CR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.