ReviewCurrent opinion in rheumatology2009
Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis.
Review in Current opinion in rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis.Arthritis research & therapy · 2013Trial
- Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases.International journal of plant, animal and environmental sciences · 2024Article
- Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Stromal vascular fraction in the treatment of myositis.Cell death discovery · 2023Review
- Review
- Autophagy and inflammation in ischemic stroke.Neural regeneration research · 2020Review
- The Immune Response and the Pathogenesis of Idiopathic Inflammatory Myositis: a Critical Review.Clinical reviews in allergy & immunology · 2017Review
- Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats.Neural regeneration research · 2014Article
- New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis.Current rheumatology reports · 2014Review
- Innate immune-response mechanisms in dermatomyositis: an update on pathogenesis, diagnosis and treatment.Drugs · 2014Review
- Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.Arthritis and rheumatism · 2013Article
- Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health?The Journal of frailty & aging · 2013Article
- The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage.Arthritis and rheumatism · 2011Article
- Cutting edge issues in polymyositis.Clinical reviews in allergy & immunology · 2011Review
- Pathogenesis, classification and treatment of inflammatory myopathies.Nature reviews. Rheumatology · 2011Review
- Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis.Arthritis and rheumatism · 2011Article
- Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy.PloS one · 2011Article
- Novel therapeutic approaches for inclusion body myositis.Current opinion in rheumatology · 2010Review
- Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction.BioFactors (Oxford, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewRecent literature in inflammatory myopathies suggests that both immune (cell-mediated and humoral) and nonimmune [endoplasmic reticulum (ER) stress and autophagy] mechanisms play a role in muscle fiber damage and dysfunction. This review describes these findings and discusses their relevance to disease pathogenesis and therapy. RECENT
findingsRecent studies highlight the role of ER stress response, especially the roles of hexose-6-phosphate dehydrogenase and ER-anchored RING finger E3 ligase in the activation of unfolded protein response and the formation of vacuoles and inclusions in myopathies. Several studies investigated the link between inflammation and the beta-amyloid-associated muscle fiber degeneration and loss of muscle function. Likewise, the roles of ER stress and autophagy in skeletal muscle damage have been explored in multiple muscle diseases. SUMMARY: Current data indicate that the ER stress, nuclear factor-kappaB pathway and autophagy are active in the skeletal muscle of myositis patients, and the proinflammatory nuclear factor-kappaB pathway connects the immune and nonimmune pathways of muscle damage. The relative contributions of each of these pathways to muscle fiber damage are currently unclear. Therefore, further defining the role of these pathways in disease pathogenesis should help to design effective therapeutic agents for these diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.