Evidence map›Paper›PMID 19713519›Full record

ReviewScience (New York, N.Y.)2009

Antibiotics for emerging pathogens.

Michael A Fischbach, Christopher T Walsh

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 652 papers.

0numbers the graph read from it
0cells of the map it votes in
652citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

652 citing papers in PubMed.

  1. Article
  2. Molecular Profiling of Soil-DerivedCurrent issues in molecular biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. CuJournal of nanobiotechnology · 2025
    Article
  8. Article
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  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Microbiota Dysbiosis inMicroorganisms · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Metallic nanoparticles: a promising novel therapeutic tool against antimicrobial resistance and spread of superbugs.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review

592 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael A FischbachDepartment of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. fischbach@fischbachgroup.org
Christopher T Walsh

Funding

Modular Enzymatic Assembly Lines for AntibioticsR01GM020011 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WALSH, CHRISTOPHER T · 1985 to 2013
$8.2M
The Vancomycin Biosynthetic Assembly lineR01GM049338 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALSH, CHRISTOPHER T · 1993 to 2012
$6.2M
Siderophore Synthetases in Three Bacterial PathogensR01AI042738 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALSH, CHRISTOPHER T · 1998 to 2011
$5.0M
ENZYMATIC REACTION MECHANISMSR37GM020011 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WALSH, CHRISTOPHER A · 1986 to 1995
–
NIAID NIH HHS R01 AI042738NIGMS NIH HHS GM20011NIGMS NIH HHS GM49338NIGMS NIH HHS R01 GM020011NIGMS NIH HHS R01 GM049338
6 · The paper itself

Abstract

Antibiotic-resistant strains of pathogenic bacteria are increasingly prevalent in hospitals and the community. New antibiotics are needed to combat these bacterial pathogens, but progress in developing them has been slow. Historically, most antibiotics have come from a small set of molecular scaffolds whose functional lifetimes have been extended by generations of synthetic tailoring. The emergence of multidrug resistance among the latest generation of pathogens suggests that the discovery of new scaffolds should be a priority. Promising approaches to scaffold discovery are emerging; they include mining underexplored microbial niches for natural products, designing screens that avoid rediscovering old scaffolds, and repurposing libraries of synthetic molecules for use as antibiotics.

Indexed as

Anti-Bacterial AgentsDrug DiscoveryTechnology, PharmaceuticalAnimalsBacterial InfectionsCommunicable Diseases, EmergingDrug DesignDrug Resistance, BacterialDrug Resistance, Multiple, BacterialGram-Negative BacteriaHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMycobacterium tuberculosisSmall Molecule LibrariesStaphylococcus aureusAnti-Bacterial AgentsSmall Molecule Libraries

Identifiers

PMID19713519
PMCPMC2802854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.