ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice.Nature communications · 2025Article
- Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague-Dawley Rats.Molecular neurobiology · 2025Article
- Article
- Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects.Molecular psychiatry · 2022Article
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
- Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model.Developmental neuroscience · 2016Article
- Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats.Developmental neuroscience · 2015Article
- Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development.Annals of neurology · 2012Article
- Stress-induced impairments in prefrontal-mediated behaviors and the role of the N-methyl-D-aspartate receptor.Neuroscience · 2012Review
- Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.Experimental neurology · 2012Article
- Ultrastructural relationship between the mu opioid receptor and its interacting protein, GPR177, in striatal neurons.Brain research · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The striatum plays a major role in both motor control and learning and memory, including executive function and "behavioral flexibility." Lesion, temporary inactivation, and infusion of an N-methyl-d-aspartate (NMDA)-receptor antagonist into the dorsomedial striatum (dmSTR) impair reversal learning in adult rats. Systemic administration of MK-801 disrupts reversal learning in developing rats, as reported in an earlier work by Chadman et al., but it is not known whether NMDA-receptor function within the dmSTR plays a role in this effect. In Experiment 1, reversal learning was dose-dependently impaired following bilateral dmSTR administration of MK-801 (either 2.5 or 5.0 microg) only during the reversal phase relative to saline in postnatal day (P) 26 rats. In Experiment 2, separate groups of P26 rats were trained on the same reversal learning task, but were administered bilateral dmSTR infusions during acquisition only (MK-SAL), reversal only (SAL-MK), both phases (MK-MK), or neither phase (SAL-SAL). The MK-801 effect was specific to the reversal training phase. The drug did not alter acquisition of the initial discrimination. Analysis of the pattern of errors indicates that dmSTR MK-801 treatment increased perseveration of the choice response trained in acquisition. NMDA receptors in the dmSTR play a role in reversal learning in the weanling rat.
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Registered trials
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