ArticleJournal of the American Society of Nephrology : JASN2009
Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Single-cell sequencing reveals peritoneal environment and insights into fibrosis in CAPD patients.iScience · 2023Article
- Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis.International journal of molecular sciences · 2023Review
- Transition of lymphocyte subsets in peritoneal dialysis effluent and its relationship to peritoneal damage.Journal of rural medicine : JRM · 2021Article
- Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome.International journal of molecular sciences · 2020Review
- Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution.BMC nephrology · 2019Article
- Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes.Kidney international · 2017Article
- Resident memory T cells in human health and disease.Science translational medicine · 2015Review
- Paricalcitol reduces peritoneal fibrosis in mice through the activation of regulatory T cells and reduction in IL-17 production.PloS one · 2014Article
- Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients.Journal of the American Society of Nephrology : JASN · 2013Article
- Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Pathophysiological changes to the peritoneal membrane during PD-related peritonitis: the role of mesothelial cells.Mediators of inflammation · 2012Review
- The local inflammatory responses to infection of the peritoneal cavity in humans: their regulation by cytokines, macrophages, and other leukocytes.Mediators of inflammation · 2012Review
- Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011Article
- Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection.PLoS pathogens · 2011Article
- CD4+ T cells, human cytomegalovirus and end-stage renal disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011Article
- Article
- Intraperitoneal IL-6 signaling in incident patients treated with icodextrin and glucose bicarbonate/lactate-based peritoneal dialysis solutions.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency and severity of episodes of peritonitis adversely affect the structure and function of the peritoneal membrane in patients treated with peritoneal dialysis (PD), but the underlying mechanisms are not well understood. Alterations in the phenotype and function of resident peritoneal cells may contribute. Because effector memory T cells play a pivotal role in maintaining peripheral tissue immunity, we hypothesized that these cells may initiate or perpetuate the peritoneal inflammatory response. Here, we characterized the phenotype and effector function of peritoneal memory T cells. We found that functional effector memory T cells capable of mounting long-term recall responses enrich the peritoneal cavity of PD patients. Peritoneal T cells were able to mount a Th1-polarized response to recall antigens, and these responses were greater in peritoneal T cells compared with T cells in the peripheral blood. We also observed that the peritoneal T cells had altered telomeres; some cells had ultrashort telomeres, suggesting a highly differentiated local population. In summary, we describe a resident population of memory T cells in the peritoneum of PD patients and speculate that these cells form part of the first line of defense against invading pathogens.
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