ArticleVirology2009
Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Virus-mediated immunosuppression in head and neck cancer.Oncogene · 2025Review
- Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use.Signal transduction and targeted therapy · 2025Review
- Two conserved amino acids differentiate the biology of high-risk and low-risk HPV E5 proteins.Journal of medical virology · 2022Article
- Cell-Cell Fusion Mediated by Viruses and HERV-Derived Fusogens in Cancer Initiation and Progression.Cancers · 2021Review
- The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis.Viruses · 2021Review
- Characteristics and Functions of the Yip1 Domain Family (YIPF), Multi-Span Transmembrane Proteins Mainly Localized to the Golgi Apparatus.Frontiers in cell and developmental biology · 2019Review
- Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology.Frontiers in oncology · 2019Review
- HPV 16 E5 oncoprotein is expressed in early stage carcinogenesis and can be a target of immunotherapy.Human vaccines & immunotherapeutics · 2017Article
- Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses.Journal of cellular physiology · 2016Review
- Binucleated HeLa cells are formed by cytokinesis failure in starvation and keep the potential of proliferation.Cytotechnology · 2016Article
- Review
- YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins.Scientific reports · 2015Article
- The E5 proteins.Virology · 2013Review
- Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.Cellular oncology (Dordrecht, Netherlands) · 2012Review
- Papillomavirus E5: the smallest oncoprotein with many functions.Molecular cancer · 2011Review
- The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification.Journal of virology · 2010Article
- Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication.Virology · 2010Article
- High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer.Virology journal · 2010Article
- Membrane orientation of the human papillomavirus type 16 E5 oncoprotein.Journal of virology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Human papillomavirus (HPV) is a non-enveloped DNA virus with an approximately 8000 base pair genome. Infection with certain types of HPV is associated with cervical cancer, although the molecular mechanism by which HPV induces carcinogenesis is poorly understood. Three genes encoded by HPV16 are regarded as oncogenic - E5, E6, and E7. The role of E5 has been controversial. Expression of HPV16 E5 causes cell-cell fusion, an event that can lead to increased chromosomal instability, particularly in the presence of cell cycle checkpoint inhibitors like HPV16 E6 and E7. Using biochemical and cell biological assays to better understand HPV16 E5, we find that HPV16 E5 localizes to the plasma membrane with an intracellular amino terminus and an extracellular carboxyl-terminus. Further, HPV16 E5 must be expressed on both cells for cell fusion to occur. When the extracellular epitope of HPV16 E5 is targeted with an antibody, the number of bi-nucleated cells decreases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.