ArticleDevelopmental biology2009
Myosin-X is critical for migratory ability of Xenopus cranial neural crest cells.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Prioritization of non-coding elements involved in non-syndromic cleft lip with/without cleft palate through genome-wide analysis ofHGG advances · 2023Article
- Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Review
- Phenotypic analysis of Myo10 knockout (Myo10Scientific reports · 2019Article
- MMP14 Regulates Cranial Neural Crest Epithelial-to-Mesenchymal Transition and Migration.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.Scientific reports · 2018Article
- Genetic Requirement ofPlastic and reconstructive surgery. Global open · 2018Article
- Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.Scientific reports · 2017Article
- Vestigial-like 3 is a novel Ets1 interacting partner and regulates trigeminal nerve formation and cranial neural crest migration.Biology open · 2017Article
- Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus.Scientific reports · 2016Article
- Myosin X regulates neuronal radial migration through interacting with N-cadherin.Frontiers in cellular neuroscience · 2015Article
- Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.The Journal of clinical investigation · 2014Article
- Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development.Developmental biology · 2013Article
- Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons.The Journal of biological chemistry · 2012Article
- Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center.Genesis (New York, N.Y. : 2000) · 2012Review
- Differential regulation of myosin X movements by its cargos, DCC and neogenin.Journal of cell science · 2012Article
- Myosin-X: a MyTH-FERM myosin at the tips of filopodia.Journal of cell science · 2011Review
- Structural basis of the myosin X PH1(N)-PH2-PH1(C) tandem as a specific and acute cellular PI(3,4,5)P(3) sensor.Molecular biology of the cell · 2011Article
- Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The neural crest is a highly migratory cell population, unique to vertebrates, that forms much of the craniofacial skeleton and peripheral nervous system. In exploring the cell biological basis underlying this behavior, we have identified an unconventional myosin, myosin-X (Myo10) that is required for neural crest migration. Myo10 is highly expressed in both premigratory and migrating cranial neural crest (CNC) cells in Xenopus embryos. Disrupting Myo10 expression using antisense morpholino oligonucleotides leads to impaired neural crest migration and subsequent cartilage formation, but only a slight delay in induction. In vivo grafting experiments reveal that Myo10-depleted CNC cells migrate a shorter distance and fail to segregate into distinct migratory streams. Finally, in vitro cultures and cell dissociation-reaggregation assays suggest that Myo10 may be critical for cell protrusion and cell-cell adhesion. These results demonstrate an essential role for Myo10 in normal cranial neural crest migration and suggest a link to cell-cell interactions and formation of processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.