ArticleComparative medicine2009
Immune response to and histopathology of Campylobacter jejuni infection in ferrets (Mustela putorius furo).
Article in Comparative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- IgA binding characteristics of golden hamster and ferret Fcα receptors.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Preharvest Control ofMicroorganisms · 2025Review
- Small worms big discoveries:Frontiers in cellular and infection microbiology · 2025Review
- Effect of dietary medicinal plants on physiological responses of broiler chickens challenged with Campylobacter jejuni.Veterinary medicine and science · 2024Article
- Gut metabolite L-lactate supportsProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Systematic Review on the Role of Wildlife as Carriers and Spreaders ofAnimals : an open access journal from MDPI · 2023Review
- The Host Cellular Immune Response to Infection by Campylobacter Spp. and Its Role in Disease.Infection and immunity · 2021Review
- Induction of neutrophil extracellular traps by Campylobacter jejuni.Cellular microbiology · 2020Article
- Distribution of genes related to Type 6 secretion system and lipooligosaccharide that induced ganglioside mimicry amongGut pathogens · 2020Article
- The Host Antimicrobial Protein Calgranulin C Participates in the Control of Campylobacter jejuni Growth via Zinc Sequestration.Infection and immunity · 2018Article
- Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration.European journal of microbiology & immunology · 2015Article
- Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?Cell communication and signaling : CCS · 2013Review
- Diagnosis of liver disease in domestic ferrets (Mustela putorius).The veterinary clinics of North America. Exotic animal practice · 2013Review
- Isolation and characterization of microsatellite markers in the domestic ferret (Mustela putorius furo).International journal of molecular sciences · 2012Article
- The chronic gastrointestinal consequences associated with campylobacter.Current gastroenterology reports · 2012Review
- Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling.Gastroenterology · 2012Article
- Probiotic colonization of the adherent mucus layer of HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties.Infection and immunity · 2010Article
- Transcriptome sequencing and development of an expression microarray platform for the domestic ferret.BMC genomics · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni is 1 of the most common enteric bacterial pathogens worldwide. The mechanisms of pathogenesis remain obscure, in part because of limitations of small animal models. Young ferrets develop diarrhea when fed C. jejuni, but their pathology and the immune response after infection have not been examined in detail. In the present study, we examined the pathogenesis of C. jejuni CG8421 and associated immune responses in ferrets. After oral infection with C. jejuni CG8421, 86.7% of the animals developed diarrhea and inflammatory responses that were similar to those seen in human infection. Pronounced histopathologic changes in the colonic mucosa of infected animals were observed during the acute phase (days 1 through 3) of infection. Electron micrographs of colonic epithelium revealed disruption of the villi and internalized bacteria that were not within membrane vacuoles. During the acute phase, C. jejuni was isolated from the livers of 7 of 9 (78%) animals, and bacteria were visualized immunohistochemically in the livers from 5 of the 7 animals (71%) from which C. jejuni was isolated. A vigorous systemic and mucosal immune response to Campylobacter antigens was elicited after infection of ferrets. The data presented contribute to the current knowledge of the pathogenicity of and immunologic response to C. jejuni CG8421 in ferrets and better understanding of this model.
Indexed as
Identifiers
19712577PMC2779212W118868646What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.