ArticleThe Journal of infectious diseases2009
Inhibition of dendritic cell maturation by group A Streptococcus.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Streptokinase is dispensable in Streptococcus dysgalactiae subspecies equisimilis infections of human dendritic cells.Scientific reports · 2025Article
- Group AInfection and immunity · 2024Article
- Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes.Journal of biomedical science · 2024Article
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- Lipoteichoic acid ofFrontiers in immunology · 2023Article
- An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome.BMC research notes · 2020Article
- Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway.Molecular medicine reports · 2019Article
- Serine-Rich Repeat Adhesins Contribute toFrontiers in microbiology · 2017Article
- Host responses to group a streptococcus: cell death and inflammation.PLoS pathogens · 2014Review
- Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.PLoS pathogens · 2014Article
- RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci.PLoS pathogens · 2013Article
- Article
- Postpartum group a Streptococcus sepsis and maternal immunology.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Review
- 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.Journal of leukocyte biology · 2011Article
- Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae.Clinical and vaccine immunology : CVI · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to group A Streptococcus (GAS) has been shown to induce maturation of dendritic cells (DC).
methodsTo identify bacterial determinants that modulate DC activation in response to GAS infection, we analyzed the induction of maturation in human monocyte-derived DC following exposure to GAS clinical isolates.
resultsUnexpectedly, only 6 of 24 GAS strains tested induced surface expression of major histocompatibility complex class II and costimulatory molecules CD80 and CD83 to levels consistent with DC maturation. Rather, the majority of the strains did not promote DC maturation, and many triggered DC apoptosis. GAS strains that failed to induce DC maturation were those that produced abundant hyaluronic acid (HA) capsular polysaccharide and/or large amounts of the cytotoxin streptolysin O (SLO). By use of isogenic mutants deficient in HA and/or SLO, we determined that GAS inhibits DC maturation through 2 distinct mechanisms: (1) inhibition of bacterial binding and/or phagocytosis by the HA capsule and (2) SLO-mediated induction of DC apoptosis by intracellular GAS.
conclusionsThese results demonstrate that GAS virulence factors modulate maturation and survival of human DC, effects that are likely to have a critical impact on activation of innate and adaptive immune responses to this important human pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.