Trial reportInfection control and hospital epidemiology2009
Impact of an antimicrobial utilization program on antimicrobial use at a large teaching hospital: a randomized controlled trial.
Trial report in Infection control and hospital epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00552838 (The Impact of an Antimicrobial Utilization Program on Antimicrobial Use in a Large Public Hospital), which is not on this map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of an Antimicrobial Utilization Program on Antimicrobial Use in a Large Public Hospital: A Randomized Controlled Trial
Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A systematic review and meta-analysis to identify behavioural content and active ingredients of antimicrobial stewardship education and training interventions in hospital-based care settings.Antimicrobial resistance and infection control · 2025Pooled it
- Efficacy of telemedicine-based antimicrobial stewardship program to combat antimicrobial resistance: A systematic review and meta-analysis.Journal of telemedicine and telecare · 2025Pooled it
- Academic Detailing Interventions and Evidence-Based Prescribing: A Systematic Review.JAMA network open · 2025Pooled it
- Nudge strategies to improve healthcare providers' implementation of evidence-based guidelines, policies and practices: a systematic review of trials included within Cochrane systematic reviews.Implementation science : IS · 2020Pooled it
- Interventions to improve antibiotic prescribing practices for hospital inpatients.The Cochrane database of systematic reviews · 2017Pooled it
- Educational interventions to improve prescription and dispensing of antibiotics: a systematic review.BMC public health · 2014Pooled it
- Impact of the ABxSG Mobile Application on Antibiotic Prescribing: An Interrupted Time Series Study.Antibiotics (Basel, Switzerland) · 2025Article
- Correct sepsis classification-A must for antimicrobial stewardship: A longitudinal observational study.World journal of critical care medicine · 2025Article
- Effectiveness of Quality Use of Medicines (QUM) Programs and Strategies in Saudi Arabia: A Narrative Review.Drug, healthcare and patient safety · 2025Review
- Validation of short culture method for rapid bacterial identification of blood cultures via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The Journal of antimicrobial chemotherapy · 2024Observational
- Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in tertiary hospital settings in Singapore.Frontiers in public health · 2024Article
- The use of telehealth-supported stewardship activities in acute-care and long-term care settings: An implementation effectiveness trial.Infection control and hospital epidemiology · 2023Article
- WHO/INRUD prescribing indicators among tertiary regional referral hospitals in Dar es Salaam, Tanzania: a call to strengthen antibiotic stewardship programmes.JAC-antimicrobial resistance · 2023Article
- An Implementation Roadmap for Establishing Remote Infectious Disease Specialist Support for Consultation and Antibiotic Stewardship in Resource-Limited Settings.Open forum infectious diseases · 2022Review
- Antibiotic stewardship implementation at hospitals without on-site infectious disease specialists: A qualitative study.Infection control and hospital epidemiology · 2022Article
- Compliance with the 4Ds of antimicrobial stewardship practice in a tertiary care centre.JAC-antimicrobial resistance · 2021Article
- Guidelines on Implementing Antimicrobial Stewardship Programs in Korea.Infection & chemotherapy · 2021Review
- Core Elements for Successful Implementation of Antimicrobial Stewardship Programs.Infection & chemotherapy · 2021Review
- WHO/INRUD core prescribing indicators and antibiotic utilization patterns among primary health care facilities in Ilala district, Tanzania.JAC-antimicrobial resistance · 2021Article
- Predictive modeling of bacterial infections and antibiotic therapy needs in critically ill adults.Journal of biomedical informatics · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMultidisciplinary antimicrobial utilization teams (AUTs) have been proposed as a mechanism for improving antimicrobial use, but data on their efficacy remain limited.
objectiveTo determine the impact of an AUT on antimicrobial use at a teaching hospital.
designRandomized controlled intervention trial.
settingA 953-bed, public, university-affiliated, urban teaching hospital. PATIENTS: Patients who were given selected antimicrobial agents (piperacillin-tazobactam, levofloxacin, or vancomycin) by internal medicine ward teams.
interventionTwelve internal medicine teams were randomly assigned monthly: 6 teams to an intervention group (academic detailing by the AUT) and 6 teams to a control group that was given indication-based guidelines for prescription of broad-spectrum antimicrobials (standard of care), during a 10-month study period. MEASUREMENTS: Proportion of appropriate empirical, definitive (therapeutic), and end (overall) antimicrobial usage.
resultsA total of 784 new prescriptions of piperacillin-tazobactam, levofloxacin, and vancomycin were reviewed. The proportion of antimicrobial prescriptions written by the intervention teams that was considered to be appropriate was significantly higher than the proportion of antimicrobial prescriptions written by the control teams that was considered to be appropriate: 82% versus 73% for empirical (risk ratio [RR], 1.14; 95% confidence interval [CI], 1.04-1.24), 82% versus 43% for definitive (RR, 1.89; 95% CI, 1.53-2.33), and 94% versus 70% for end antimicrobial usage (RR, 1.34; 95% CI, 1.25-1.43). In multivariate analysis, teams that received feedback from the AUT alone (adjusted RR, 1.37; 95% CI, 1.27-1.48) or from both the AUT and the infectious diseases consultation service (adjusted RR, 2.28; 95% CI, 1.64-3.19) were significantly more likely to prescribe end antimicrobial usage appropriately, compared with control teams.
conclusionsA multidisciplinary AUT that provides feedback to prescribing physicians was an effective method in improving antimicrobial use. Trial registration. ClinicalTrials.gov identifier: NCT00552838.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.