ArticleBiomacromolecules2009
Movements of HIV-virions in human cervical mucus.
Article in Biomacromolecules, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- The link between gut microbiota and multiple sclerosis from the perspective of barrier function.Frontiers in immunology · 2025Review
- Interactions between microbiota and cervical epithelial, immune, and mucus barrier.Frontiers in cellular and infection microbiology · 2023Review
- Mucus-Inspired Dynamic Hydrogels: Synthesis and Future Perspectives.Journal of the American Chemical Society · 2022Review
- HIV-1 Entry and Prospects for Protecting against Infection.Microorganisms · 2021Review
- The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.PLoS pathogens · 2020Article
- Comparisons of Human Immunodeficiency Virus Type 1 Envelope Variants in Blood and Genital Fluids near the Time of Male-to-Female Transmission.Journal of virology · 2019Article
- A reaction-diffusion within-host HIV model with cell-to-cell transmission.Journal of mathematical biology · 2018Article
- Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling.International journal of nanomedicine · 2018Review
- A Model for the Transient Subdiffusive Behavior of Particles in Mucus.Biophysical journal · 2017Article
- Imaging and tracking HIV viruses in human cervical mucus.Journal of biomedical optics · 2016Article
- Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract.PLoS pathogens · 2016Article
- Biopolymeric Mucin and Synthetic Polymer Analogs: Their Structure, Function and Role in Biomedical Applications.Polymers · 2016Review
- Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion.Biophysical journal · 2015Article
- Microscale imaging of cilia-driven fluid flow.Cellular and molecular life sciences : CMLS · 2015Review
- The effects of reproductive hormones on the physical properties of cervicovaginal fluid.American journal of obstetrics and gynecology · 2014Article
- HIV-1 vaginal transmission: cell-free or cell-associated virus?American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Histocultures (tissue explants) in human retrovirology.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Human cervicovaginal mucus contains an activity that hinders HIV-1 movement.Mucosal immunology · 2013Article
- Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network.The Journal of infectious diseases · 2012Article
- Selective transmission of R5 HIV-1 variants: where is the gatekeeper?Journal of translational medicine · 2011Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Time-resolved confocal microscopy and fluorescence correlation spectroscopy were used to examine the movements of fluorescently labeled HIV-virions (approximately 100 nm) added to samples of human cervical mucus. Particle-tracking analysis indicates that the motion of most virions is decreased 200-fold compared to that in aqueous solution and is not driven by typical diffusion. Rather, the time-dependence of their ensemble-averaged mean-square displacements is proportional to tau(alpha) + v(2)tau(2), describing a combination of anomalous diffusion (alpha approximately 0.3) and flow-like behavior, with tau being the lag time. We attribute the flow-like behavior to slowly relaxing mucus matrix that follows mechanical perturbations such as stretching and twisting of the sample. Further analysis of the tracks and displacements of individual virions indicates differences in the local movements among the virions, including constrained motion and infrequent jumps, perhaps due to abrupt changes in matrix structure. Changes in the microenvironments due to slow structural changes may facilitate movement of the virions, allowing them to reach the epithelial layer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.