ArticleThe Journal of comparative neurology2009
Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Fasciclin 2 Cooperates with Discs Large to Maintain Epithelial Architecture.bioRxiv : the preprint server for biology · 2026Article
- Conserved roles of engrailed: patterning tissues and specifying cell types.Development (Cambridge, England) · 2024Review
- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- A clinically-relevant residue of POLR1D is required for Drosophila development.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Cloning and mutagenetic modification of the firefly luciferase gene and its use for bioluminescence microscopy ofBiochemistry and biophysics reports · 2020Article
- Lineage-specific determination of ring neuron circuitry in the central complex ofBiology open · 2019Article
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- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments.The Journal of comparative neurology · 2018Article
- Developmental analysis of the dopamine-containing neurons of the Drosophila brain.The Journal of comparative neurology · 2017Article
- The insect central complex as model for heterochronic brain development-background, concepts, and tools.Development genes and evolution · 2016Review
- Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain.Developmental neurobiology · 2016Article
- Lineage-associated tracts defining the anatomy of the Drosophila first instar larval brain.Developmental biology · 2015Article
- Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors.Developmental biology · 2015Article
- Hydroxyurea-mediated neuroblast ablation establishes birth dates of secondary lineages and addresses neuronal interactions in the developing Drosophila brain.Developmental biology · 2015Article
- Postembryonic lineages of the Drosophila brain: I. Development of the lineage-associated fiber tracts.Developmental biology · 2013Article
- Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones.Developmental biology · 2013Article
- A small cohort of FRU(M) and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster.BMC neuroscience · 2013Article
- Development-based compartmentalization of the Drosophila central brain.The Journal of comparative neurology · 2010Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila brain is a highly complex structure composed of thousands of neurons that are interconnected in numerous exquisitely organized neuropil structures such as the mushroom bodies, central complex, antennal lobes, and other specialized neuropils. While the neurons of the insect brain are known to derive in a lineage-specific fashion from a stereotyped set of segmentally organized neuroblasts, the developmental origin and neuromeric organization of the neuropil formed by these neurons is still unclear. In this study we used genetic labeling techniques to characterize the neuropil innervation pattern of engrailed-expressing brain lineages of known neuromeric origin. We show that the neurons of these lineages project to and form most arborizations, in particular all of their proximal branches, in the same brain neuropil compartments in embryonic, larval and adult stages. Moreover, we show that engrailed-positive neurons of differing neuromeric origin respect boundaries between neuromere-specific compartments in the brain. This is confirmed by an analysis of the arborization pattern of empty spiracles-expressing lineages. These findings indicate that arborizations of lineages deriving from different brain neuromeres innervate a nonoverlapping set of neuropil compartments. This supports a model for neuromere-specific brain neuropil, in which a given lineage forms its proximal arborizations predominantly in the compartments that correspond to its neuromere of origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.