ArticleEndocrine2009
The association of adiposity with parathyroid hormone in healthy older adults.
Article in Endocrine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Body Size and the Risk of Primary Hyperparathyroidism in Women: A Cohort Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- Trial
- Vitamin D and hyperparathyroidism in obesity.The Journal of clinical endocrinology and metabolism · 2011Trial
- Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study.Journal of the Endocrine Society · 2026Article
- Diuretic Use and Serum Phosphate: Rotterdam Study and UK Biobank.Journal of the Endocrine Society · 2024Article
- Vitamin D Status in Patients before Thyroidectomy.International journal of molecular sciences · 2023Article
- The Influence of Obesity, Ovariectomy, and Greenshell Mussel Supplementation on Bone Mineral Density in Rats.JBMR plus · 2022Article
- Effect of Age and Sodium Alendronate on Femoral Fracture Repair: Biochemical and Biomechanical Study in Rats.Frontiers in cell and developmental biology · 2021Article
- Predictive Factors of Secondary Normocalcemic Hyperparathyroidism after Roux-en-Y Gastric Bypass.International journal of endocrinology · 2018Article
- Obesity is a concern for bone health with aging.Nutrition research (New York, N.Y.) · 2017Review
- Visceral adiposity is a predictor of parathyroid hormone levels in healthy adults.Journal of endocrinological investigation · 2016Article
- Associations of Age, BMI, and Years of Menstruation with Proximal Femur Strength in Chinese Postmenopausal Women: A Cross-Sectional Study.International journal of environmental research and public health · 2016Article
- Obesity in the Context of Aging: Quality of Life Considerations.PharmacoEconomics · 2015Review
- Low dietary calcium and obesity: a comparative study in genetically obese and normal rats during early growth.European journal of nutrition · 2014Article
- The role of osteocalcin in human glucose metabolism: marker or mediator?Nature reviews. Endocrinology · 2013Review
- Hormonal and dietary influences on true fractional calcium absorption in women: role of obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Bone metabolism in obesity and weight loss.Annual review of nutrition · 2012Review
- Metabolic syndrome and the risk of calcium stones.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats.Journal of bone and mineral metabolism · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Elevated parathyroid hormone (PTH) is a risk factor for increased morbidity and mortality. PTH levels increase with adiposity in older adults but the basis for this association is unclear. The objective of this study was to examine the association of percent body fat (%Fat) with serum PTH in 307 older men and women and to determine the extent to which it may be explained by vitamin D status, bone turnover, calcium metabolism, and glucose homeostasis. The data are from the baseline visit of a clinical trial of calcium and vitamin D to prevent bone loss. %Fat was measured by dual-energy X-ray absorptiometry and fasting blood and urine samples were collected. Serum PTH levels increased by about 0.4 pmol/l per 10 unit increase in percent body fat (P = 0.003). The variables that we examined, including plasma 25-hydroxyvitamin D and serum osteocalcin, calcium, phosphorus, and insulin explained only a small proportion of this association (18%). Further work is needed to identify the mediators of the higher PTH levels in subjects with greater adiposity. This is important in view of worldwide increases in overweight and obesity and the potential contribution of elevated PTH to morbidity and mortality.
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Registered trials
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