ReviewJournal of neurology2009
Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.
Review in Journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06422208 (A Phase 1 Clinical Trial of Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1 Clinical Trial of Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease
Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Cell-based regenerative interventions in Parkinson's disease: Overcoming pharmacological limitations.Acta pharmaceutica Sinica. B · 2026Review
- Neuronal threshold functions: Determining symptom onset in neurological disorders.Progress in neurobiology · 2024Review
- Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats.NPJ Parkinson's disease · 2024Article
- Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells.Frontiers in genetics · 2022Review
- The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats.Neurobiology of disease · 2021Article
- Glial cells in intracerebral transplantation for Parkinson's disease.Neural regeneration research · 2020Review
- Mesenchymal Stem Cells with Granulocyte Colony-Stimulating Factor Reduce Stress Oxidative Factors in Parkinson's DiseaseIranian biomedical journal · 2020Article
- Stem cell therapy for Parkinson's disease: safety and modeling.Neural regeneration research · 2020Review
- Parkinson's Disease and the Gut: Future Perspectives for Early Diagnosis.Frontiers in neuroscience · 2020Review
- Modeling Parkinson's Disease With the Alpha-Synuclein Protein.Frontiers in pharmacology · 2020Review
- Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients.Frontiers in cellular neuroscience · 2020Review
- Treatment of Parkinson's Disease through Personalized Medicine and Induced Pluripotent Stem Cells.Cells · 2019Review
- The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(The Journal of pharmacology and experimental therapeutics · 2018Article
- Parkinson's Disease Is Not Simply a Prion Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- How strong is the evidence that Parkinson's disease is a prion disorder?Current opinion in neurology · 2016Review
- A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.Nature reviews. Neuroscience · 2016Review
- Induced pluripotent stem cells and Parkinson's disease: modelling and treatment.Cell proliferation · 2016Review
- Lewy Bodies' absence in grafted dopaminergic transplants in Parkinson's Disease.Movement disorders clinical practice · 2015Article
- α-Synuclein and nonhuman primate models of Parkinson's disease.Journal of neuroscience methods · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson's disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.