ArticleMolecular vision2009
Sclera-related gene polymorphisms in high myopia.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Human aqueous humor levels of TGF- β2: relationship with axial length.BioMed research international · 2014Trial
- Changes in Ocular Biomechanics During Adolescence and Its Relationship with Lifestyle and Myopic Progression: The Oporto Myopia Study.Bioengineering (Basel, Switzerland) · 2026Article
- Reduced retinol (vitamin A) and α-tocopherol (vitamin E) blood levels and increased myeloperoxidase (MPO) activity in children with high myopia.Scientific reports · 2024Article
- IMI-Nonpathological Human Ocular Tissue Changes With Axial Myopia.Investigative ophthalmology & visual science · 2023Article
- Polymorphic Variants of Genes Encoding Angiogenesis-Related Factors in Infertile Women with Recurrent Implantation Failure.International journal of molecular sciences · 2023Article
- Fibromodulin Gene Variants (Disease markers · 2022Article
- Association of sleep quality with myopia based on different genetic risk levels.International journal of ophthalmology · 2022Article
- Correlation Between SNPs at the 3'UTR of the FGF2 Gene and Their Interaction with Environmental Factors in Han Chinese Diabetic Peripheral Neuropathy Patients.Journal of molecular neuroscience : MN · 2021Article
- Association of Myopia and Genetic Variants ofFrontiers in cell and developmental biology · 2021Article
- Corneal thinning and cornea guttata in patients with mutations in TGFB2.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2020Observational
- Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.Frontiers in physiology · 2020Article
- IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019Review
- All-trans retinoic acid stimulates the secretion of TGF-β2 via the phospholipase C but not the adenylyl cyclase signaling pathway in retinal pigment epithelium cells.BMC ophthalmology · 2019Article
- Significant Association and Increased Risk of Primary Open Angle Glaucoma withReports of biochemistry & molecular biology · 2019Article
- Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression.EBioMedicine · 2018Article
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage renal disease.Kidney research and clinical practice · 2015Article
- Oxidative stress in myopia.Oxidative medicine and cellular longevity · 2015Review
- Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice.Molecular vision · 2015Article
- The FGF2 gene in a myopia animal model and human subjects.Molecular vision · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTransforming growth factor-beta2 (TGF-beta2), basic fibroblast growth factor (bFGF), and fibromodulin (FMOD) are important extracellular matrix components of the sclera and have been shown to be associated with the development of high myopia. Our aim was to examine the association between myopia and the polymorphisms within TGF-beta2, bFGF, and FMOD.
methodsThe study group comprised of patients (n=195; age range: 17-24 years) with a spherical equivalent of -6.5 diopters (D) or a more negative refractive error. The control group comprised of individuals (n=94; age range: 17-25 years) with a spherical equivalent ranging from -0.5 D to +1.0 D. The subjects with astigmatism over -0.75 D were excluded from the study. High resolution melting (HRM) genotyping and restriction fragment length polymorphism (RFLP) genotyping were used to detect single nucleotide polymorphisms (SNPs). The polymorphisms detected were TGF-beta2 (rs7550232 and rs991967), bFGF (rs308395 and rs41348645), and FMOD (rs7543418). Moreover, a stepwise logistic regression procedure was used to detect which of the significant SNPs contributed to the main effects of myopia development.
resultsThere were significant differences in the frequency of the A allele and A/A genotype in TGF-beta2 (rs7550232; p=0.0178 and 0.03, respectively). Moreover, the haplotype distribution of haplotype 2 (Ht2; A/A) of TGF-beta2 differed significantly between the two groups (p=0.014). The results of the stepwise logistic regression procedure revealed that TGF-beta2 (rs7550232) contributed significantly to the development of high myopia.
conclusionsTGF-beta2 is an important structure of sclera and might contribute to the formation of myopia. TGF-beta2 (rs7550232) polymorphisms, A allele and A/A genotype, had a protective role against the development of high myopia.
Indexed as
Identifiers
19710942PMC2730748W2144237959What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.