ArticlePloS one2009
Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Synchronous activation of striatal cholinergic interneurons induces local serotonin release.Nature communications · 2026Article
- Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025Review
- Abnormal CaFrontiers in pharmacology · 2025Article
- Plasma serotonin levels are associated with antidepressant response to SSRIs.Journal of affective disorders · 2019Article
- Neuroimaging Predictors and Mechanisms of Treatment Response in Social Anxiety Disorder: an Overview of the Amygdala.Current psychiatry reports · 2018Review
- Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- 5-Hydroxytryptophan, a major product of tryptophan degradation, is essential for optimal replication of human parainfluenza virus.Virology · 2017Article
- Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.Molecular psychiatry · 2014Article
- Modeling of the hypothalamic-pituitary-adrenal axis-mediated interaction between the serotonin regulation pathway and the stress response using a Boolean approximation: a novel study of depression.Theoretical biology & medical modelling · 2013Article
- Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.ACS chemical neuroscience · 2013Article
- Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats.The European journal of neuroscience · 2012Article
- Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.Psychoneuroendocrinology · 2012Article
- Article
- Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.Frontiers in psychology · 2012Article
- Antidepressant response to chronic citalopram treatment in eight inbred mouse strains.Psychopharmacology · 2011Article
- Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Both synthesis and reuptake are critical for replenishing the releasable serotonin pool in Drosophila.Journal of neurochemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSerotonin (5-HT) is a neurotransmitter with important roles in the regulation of neurobehavioral processes, particularly those regulating affect in humans. Drugs that potentiate serotonergic neurotransmission by selectively inhibiting the reuptake of serotonin (SSRIs) are widely used for the treatment of psychiatric disorders. Although the regulation of serotonin synthesis may be an factor in SSRI efficacy, the effect of chronic SSRI administration on 5-HT synthesis is not well understood. Here, we describe effects of chronic administration of the SSRI citalopram (CIT) on 5-HT synthesis and content in the mouse forebrain. METHODOLOGY/PRINCIPAL
findingsCitalopram was administered continuously to adult male C57BL/6J mice via osmotic minipump for 2 days, 14 days or 28 days. Plasma citalopram levels were found to be within the clinical range. 5-HT synthesis was assessed using the decarboxylase inhibition method. Citalopram administration caused a suppression of 5-HT synthesis at all time points. CIT treatment also caused a reduction in forebrain 5-HIAA content. Following chronic CIT treatment, forebrain 5-HT stores were more sensitive to the depleting effects of acute decarboxylase inhibition. CONCLUSIONS/SIGNIFICANCE: Taken together, these results demonstrate that chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain. Furthermore, our results indicate that chronic 5-HT reuptake inhibition renders 5-HT brain stores more sensitive to alterations in serotonin synthesis. These results suggest that the regulation of 5-HT synthesis warrants consideration in efforts to develop novel antidepressant strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.