ArticleJournal of immunology (Baltimore, Md. : 1950)2009
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Control of immune cell function by the unfolded protein response.Nature reviews. Immunology · 2023Review
- Sec22b is a critical and nonredundant regulator of plasma cell maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Loss of AID exacerbates the malignant progression of CLL.Leukemia · 2022Article
- Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway.Journal of Zhejiang University. Science. B · 2022Article
- Inositol-Requiring Enzyme 1α-Mediated Synthesis of Monounsaturated Fatty Acids as a Driver of B Cell Differentiation and Lupus-like Autoimmune Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Epigenetic gene regulation in plasma cells.Immunological reviews · 2021Review
- A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.The Journal of experimental medicine · 2021Article
- Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy.Molecular cancer therapeutics · 2020Article
- Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.PLoS genetics · 2020Article
- Review
- Plasma cells: You are what you eat.Immunological reviews · 2019Review
- Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane.International journal of molecular sciences · 2018Review
- Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.Scientific reports · 2018Article
- Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.The Journal of cell biology · 2018Article
- IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.The Journal of clinical investigation · 2018Article
- Metabolic Links between Plasma Cell Survival, Secretion, and Stress.Trends in immunology · 2018Review
- Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Phosphatidylcholine as a metabolic cue for determining B cell fate and function.Cellular immunology · 2016Article
- Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation.The Journal of biological chemistry · 2016Article
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.Cancer research · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The accumulation of misfolded secreted IgM in the endoplasmic reticulum (ER) of X-box binding protein 1 (XBP-1)-deficient B cells has been held responsible for the inability of such cells to yield plasma cells, through the failure to mount a proper unfolded protein response. LPS-stimulated B cells incapable of secreting IgM still activate the XBP-1 axis normally, as follows: XBP-1 is turned on by cues that trigger differentiation and not in response to accumulation of unfolded IgM, but the impact of XBP-1 deficiency on glycoprotein folding and assembly has not been explored. The lack of XBP-1 compromised neither the formation of functional hen egg lysozyme-specific IgM nor the secretion of free kappa-chains. Although XBP-1 deficiency affects the synthesis of some ER chaperones, including protein disulfide isomerase, their steady state levels do not drop below the threshold required for proper assembly and maturation of the Igalpha/Igbeta heterodimer and MHC molecules. Intracellular transport and surface display of integral membrane proteins are unaffected by XBP-1 deficiency. Given the fact that we failed to observe any defects in folding of a variety of glycoproteins, we looked for other means to explain the requirement for XBP-1 in plasma cell development. We observed significantly reduced levels of phosphatidylcholine, sphingomyelin, and phosphatidylinositol in total membranes of XBP-1-deficient B cells, and reduced ER content. Terminal N-linked glycosylation of IgM and class I MHC was altered in these cells. XBP-1 hence has important roles beyond folding proteins in the ER.
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Registered trials
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