ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Central mechanisms of emesis: A role for GDF15.Neurogastroenterology and motility · 2025Review
- The Gut Microbial Lipid Metabolite 14(15)-EpETE Inhibits Substance P Release by Targeting GCG/PKA Signaling to Relieve Cisplatin-Induced Nausea and Vomiting in Rats.Journal of microbiology and biotechnology · 2024Article
- The antiemetic actions of GIP receptor agonism.American journal of physiology. Endocrinology and metabolism · 2024Review
- Evaluating proxies for motion sickness in rodent.IBRO neuroscience reports · 2023Article
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Possible involvement of central oxytocin in cisplatin-induced anorexia in rats.The journal of physiological sciences : JPS · 2018Article
- Electroacupuncture alleviates cisplatin-induced nausea in rats.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2016Article
- Appetite and body weight regulation after bariatric surgery.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Evaluating the various phases of cisplatin-induced emesis in rats.Oncology letters · 2014Article
- Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.The Journal of clinical investigation · 2014Article
- Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting.European journal of pharmacology · 2014Review
- Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations.International journal of obesity (2005) · 2013Article
- Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Anticancer agents, such as cisplatin, stimulate nausea, vomiting, and behaviors indicative of malaise. Rats and mice do not possess a vomiting response, and, therefore, in these species, the ingestion of kaolin clay (a pica response) has been used as an index of malaise. In the rat, cisplatin-induced kaolin intake is inhibited by antiemetic treatments. In addition, cisplatin activates vagal afferent fibers in the gut, and kaolin intake induced by cisplatin is largely dependent on an intact vagus. Nevertheless, little is known about the brain pathways controlling pica. We investigated the role of the lateral parabrachial nucleus (lPBN), a major visceral afferent link between the hindbrain and forebrain, in cisplatin-induced c-Fos expression and pica. Injection of cisplatin (6 mg/kg ip) produced c-Fos expression in the ventrolateral (external) lPBN, a region receiving viscerosensory input. In rats with bilateral ibotenic acid lPBN lesions, cisplatin treatment substantially increased kaolin intake compared with controls ( approximately 30 g vs. approximately 5 g, respectively, over 24 h). Food intake was reduced by cisplatin treatment and by apomorphine, an emetic agent that acts centrally. Unlike cisplatin, however, apomorphine stimulated kaolin intake to a similar degree in both the lesioned and control rats, suggesting that lPBN damage neither produces nonspecific effects nor enhances malaise in general. These data suggest that lPBN-lesioned animals not only demonstrate pica after cisplatin treatment, but, in fact, show an exaggerated response that is greatly in excess of any treatment known to produce kaolin intake in rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.