ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Dynamic associations in the cerebellar-motoneuron network during motor learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Cerebellar interpositus nucleus exhibits time-dependent errors and predictive responses.NPJ science of learning · 2024Article
- Luvadaxistat: A Novel Potent and Selective D-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia.Neurochemical research · 2023Article
- The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome.Molecular autism · 2023Article
- Functional properties of eyelid conditioned responses and involved brain centers.Frontiers in behavioral neuroscience · 2022Review
- The Macaque Cerebellar Flocculus Outputs a Forward Model of Eye Movement.Frontiers in integrative neuroscience · 2019Article
- Long-Lasting Response Changes in Deep Cerebellar NucleiFrontiers in cellular neuroscience · 2019Article
- Spike sorting based on shape, phase, and distribution features, and K-TOPS clustering with validity and error indices.Scientific reports · 2018Article
- Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.Cell reports · 2017Article
- Theta synchronization between medial prefrontal cortex and cerebellum is associated with adaptive performance of associative learning behavior.Scientific reports · 2016Article
- Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control.Current biology : CB · 2015Article
- Article
- Spike-coding mechanisms of cerebellar temporal processing in classical conditioning and voluntary movements.Cerebellum (London, England) · 2014Review
- Consensus paper: current views on the role of cerebellar interpositus nucleus in movement control and emotion.Cerebellum (London, England) · 2013Review
- Differential contribution of hippocampal circuits to appetitive and consummatory behaviors during operant conditioning of behaving mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Motor learning of mice lacking cerebellar Purkinje cells.Frontiers in neuroanatomy · 2013Article
- Article
- Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement.Cerebellum (London, England) · 2012Review
- An agonist-antagonist cerebellar nuclear system controlling eyelid kinematics during motor learning.Frontiers in neuroanatomy · 2012Article
- Article
- Mini-review: synaptic integration in the cerebellar nuclei--perspectives from dynamic clamp and computer simulation studies.Cerebellum (London, England) · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assessed here true causal directionalities in cerebellar-motoneuron (MN) network associations during the classical conditioning of eyelid responses. For this, the firing activities of identified facial MNs and cerebellar interpositus (IP) nucleus neurons were recorded during the acquisition of this type of associative learning in alert behaving cats. Simultaneously, the eyelid conditioned response (CR) and the EMG activity of the orbicularis oculi (OO) muscle were recorded. Nonlinear association analysis and time-dependent causality method allowed us to determine the asymmetry, time delays, direction in coupling, and functional interdependences between neuronal recordings and learned motor responses. We concluded that the functional nonlinear association between the IP neurons and OO muscle activities was bidirectional and asymmetric, and the time delays in the two directions of coupling always lagged the start of the CR. Additionally, the strength of coupling depended inversely on the level of expression of eyeblink CRs, whereas causal inferences were significantly dependent on the phase information status. In contrast, the functional association between OO MNs and OO muscle activities was unidirectional and quasisymmetric, and the time delays in coupling were always of opposed signs. Moreover, information transfer in cerebellar-MN network associations during the learning process required a "driving common source" that induced the mere "modulating coupling" of the IP nucleus with the final common pathway for the eyelid motor system. Thus, it can be proposed that the cerebellum is always looking back and reevaluating its own function, using the information acquired in the process, to play a modulating-reinforcing role in motor learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.