ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intrathecal drug delivery in the era of nanomedicine.Advanced drug delivery reviews · 2020Pooled it
- Advances in Intrathecal Nanoparticle Delivery: Targeting the Blood-Cerebrospinal Fluid Barrier for Enhanced CNS Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics.ACS nano · 2018Review
- Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling.Journal of biomedical science · 2016Article
- Amphetamine manipulates monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB.Journal of biomedical science · 2016Article
- Imaging rhodopsin degeneration in vivo in a new model of ocular ischemia in living mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Article
- Anatomical, functional and molecular biomarker applications of magnetic resonance neuroimaging.Future neurology · 2015Article
- Molecular neuroimaging of post-injury plasticity.Journal of molecular neuroscience : MN · 2014Article
- Behavioral and neurochemical changes induced by repetitive combined treatments of ketamine and amphetamine in mice.Neurochemical research · 2014Article
- Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- MRI reveals differential effects of amphetamine exposure on neuroglia in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Is there a path beyond BOLD? Molecular imaging of brain function.NeuroImage · 2012Review
- Bioengineered probes for molecular magnetic resonance imaging in the nervous system.ACS chemical neuroscience · 2012Review
- Noninvasive detection of neural progenitor cells in living brains by MRI.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Advances in the application of MRI to amyotrophic lateral sclerosis.Expert opinion on medical diagnostics · 2010Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We designed phosphorothioate-modified DNA probes linked to superparamagnetic iron oxide nanoparticles (SPION) for in vivo magnetic resonance imaging (MRI) of fosB and Delta fosB mRNA after amphetamine (AMPH) exposure in mice. Specificity of both the fosB and Delta fosB probes was verified by in vitro reverse transcriptase-PCR amplification to a single fragment of total cDNA obtained from acutely AMPH-exposed mouse brains. We confirmed time-dependent uptake and retention profiles of both probes in neurons of GAD67-green fluorescent protein knock-in mice. MRI signal of SPION-labeled fosB probe delivered via intracerebroventricular route was elevated in both acutely and chronically AMPH-exposed mice; the signal was suppressed by dopaminergic receptor antagonist pretreatment. SPION-labeled Delta fosB probe signal elevation occurred only in chronically AMPH-exposed mice. The in vivo target specificity of these probes permits reliable MRI visualization of AMPH-induced differential elevations of fosB and Delta fosB mRNA in living brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.