ArticleDevelopment (Cambridge, England)2009
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 69 citations in OpenAlex.
- α-Parvin regulation of cell rearrangement is critical for ureteric bud branching morphogenesis.Science advances · 2026Article
- Kindlins regulate integrin- and growth factor-dependent ureteric bud formation.Development (Cambridge, England) · 2026Article
- Laminin Receptors in Peripheral Tissues: Functions Revealed by Analysis of Knockout Mice.The American journal of pathology · 2025Review
- Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025Review
- Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025Article
- Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.Nature communications · 2023Article
- The laminin-binding integrins regulate nuclear factor κB-dependent epithelial cell polarity and inflammation.Journal of cell science · 2021Article
- Integrin-βAmerican journal of physiology. Renal physiology · 2020Article
- β1 Integrin regulates adult lung alveolar epithelial cell inflammation.JCI insight · 2020Article
- Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.Journal of cell science · 2019Article
- The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.Matrix biology : journal of the International Society for Matrix Biology · 2019Article
- Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.Development (Cambridge, England) · 2019Article
- FGF Gradient Controls Boundary Position Between Proliferating and Differentiating Cells and Regulates Lacrimal Gland Growth Dynamics.Frontiers in genetics · 2019Article
- Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice.Frontiers in physiology · 2018Article
- Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.JCI insight · 2017Article
- Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.Development (Cambridge, England) · 2017Article
- Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.American journal of physiology. Renal physiology · 2017Article
- Integrin alpha6 maintains the structural integrity of the kidney collecting system.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- The contribution of branching morphogenesis to kidney development and disease.Nature reviews. Nephrology · 2016Review
- Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis.The Journal of cell biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
The kidney collecting system develops from branching morphogenesis of the ureteric bud (UB). This process requires signaling by growth factors such as glial cell line derived neurotrophic factor (GDNF) and fibroblast growth factors (FGFs) as well as cell extracellular matrix interactions mediated by integrins. The importance of integrin signaling in UB development was investigated by deleting integrin beta1 at initiation (E10.5) and late (E18.5) stages of development. Deletion at E10.5 resulted in a severe branching morphogenesis phenotype. Deletion at E18.5 did not alter renal development but predisposed the collecting system to severe injury following ureteric obstruction. beta1 integrin was required for renal tubular epithelial cells to mediate GDNF- and FGF-dependent signaling despite normal receptor localization and activation in vitro. Aberrations in the same signaling molecules were present in the beta1-null UBs in vivo. Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.