ArticleThe Journal of nutrition2009
Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling.Journal of medicinal food · 2016Pooled it
- Phytoestrogens and Their Health Effect.Open access Macedonian journal of medical sciences · 2019Review
- Article
- Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats.Journal of agricultural and food chemistry · 2014Article
- Crude bark extract ofReproductive medicine and biology · 2013Article
- Botanical modulation of menopausal symptoms: mechanisms of action?Planta medica · 2013Review
- Review
- Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice.The Journal of nutrition · 2012Article
- Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects.Menopause (New York, N.Y.) · 2011Article
- Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.Reproductive toxicology (Elmsford, N.Y.) · 2011Article
- The pros and cons of phytoestrogens.Frontiers in neuroendocrinology · 2010Review
- Equol: pharmacokinetics and biological actions.The Journal of nutrition · 2010Review
- Equol, via dietary sources or intestinal production, may ameliorate estrogen deficiency-induced bone loss.The Journal of nutrition · 2010Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Soy isoflavones and their metabolites, with estrogenic activity, have been considered candidates for reducing postmenopausal bone loss. In this study, we examined the effect of dietary equol, a bioactive metabolite of the soy isoflavone daidzein, on equol tissue distribution, bone parameters, and reproductive tissue activity using an adult ovariectomized (OVX) rat model. An 8-wk feeding study was conducted to compare 4 dietary treatments of equol (0, 50, 100, 200 mg/kg diet) in 6-mo-old OVX female Sprague-Dawley rats. A dose response increase in tissue equol concentrations was observed for serum, liver, kidney, and heart, and a plateau occurred at 100 mg equol/kg diet for intestine. In OVX rats receiving 200 mg equol/kg diet, femoral calcium concentration was greater than those receiving lower doses but was still less than SHAM (P < 0.05), and other bone measures were not improved. Tibia calcium concentrations were lower in OVX rats receiving 100 and 200 mg equol/kg diet compared with the OVX control rats. Trabecular bone mineral density of tibia was also lower in equol-fed OVX rats. At this dietary equol intake, uterine weight was higher (P < 0.05) than in other OVX groups but lower than the SHAM-operated intact rats. The 200 mg/kg diet dose of dietary equol significantly increased proliferative index in the uterine epithelium. Dietary equol had no stimulatory effect on mammary gland epithelium. We conclude that in OVX rats, a dietary equol dose that had modest effect on bone also exerts mild uterotropic effects.
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Registered trials
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