ArticleCritical care (London, England)2009
Effects of inducible nitric oxide synthase inhibition or norepinephrine on the neurovascular coupling in an endotoxic rat shock model.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Cerebral blood flow velocity in early-onset neonatal sepsis and its clinical significance.European journal of pediatrics · 2012Trial
- Prolonged systemic inflammation worsens impairments to astrocyte CabioRxiv : the preprint server for biology · 2025Article
- Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Adipose‑derived mesenchymal stem cell‑derived HCAR1 regulates immune response in the attenuation of sepsis.Molecular medicine reports · 2022Article
- Sepsis modulates cortical excitability and alters the local and systemic hemodynamic response to seizures.Scientific reports · 2022Article
- Effects of Reversal of Hypotension on Cerebral Microcirculation and Metabolism in Experimental Sepsis.Biomedicines · 2022Article
- Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment.Oxidative medicine and cellular longevity · 2022Review
- Seizures and Sepsis: A Narrative Review.Journal of clinical medicine · 2021Review
- Sepsis-Exacerbated Brain Dysfunction After Intracerebral Hemorrhage.Frontiers in cellular neuroscience · 2021Review
- Retinal blood flow in critical illness and systemic disease: a review.Annals of intensive care · 2020Review
- Long-term risk of seizures in adult survivors of sepsis.Neurology · 2017Article
- Supplemental carvacrol can reduce the severity of inflammation by influencing the production of mediators of inflammation.Inflammation · 2015Article
- Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock.Intensive care medicine experimental · 2014Article
- Transcranial doppler assessment of cerebral perfusion in critically ill septic patients: a pilot study.Annals of intensive care · 2013Article
- Early neurovascular uncoupling in the brain during community acquired pneumonia.Critical care (London, England) · 2012Article
- Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.Journal of neuroinflammation · 2012Article
- Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats.Journal of neuroinflammation · 2011Article
- Neuro-oxidative-nitrosative stress in sepsis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- Septic-associated encephalopathy--everything starts at a microlevel.Critical care (London, England) · 2010Review
- Cerebral microcirculation is impaired during sepsis: an experimental study.Critical care (London, England) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe inducible nitric oxide synthase (iNOS) plays a crucial role in early sepsis-related microcirculatory dysfunction. Compared to a catecholamine therapy we tested effects of a specific iNOS-inhibitor (1400W) on the microcirculatory function in the brain.
methodsSeventy SD-rats (280-310 g) were divided into 1 control and 6 sepsis groups. Sepsis groups received 1 or 5 mg/kg lipopolysaccharide (LPS) intravenously to induce a moderate or severe sepsis syndrome. Thirty minutes later rats were further randomized into subgroups receiving moderate volume therapy alone or additionally continuous norepinephrine (NE) or 1400W infusion. Separately, effects of 1400W on neurofunctional parameters were investigated in 3 rats without sepsis induction. Performing electric forepaw-stimulation evoked potentials (N2-P1 amplitude, P1-latency) and local hemodynamic responses were recorded with surface electrodes and laser Doppler over the somatosensory cortex at baseline and repeatedly after LPS administration. Cytokine levels (tumor necrosis factor-alpha (TNFalpha), interleukin-6 (IL6), interferon-gamma (IFNgamma)) and cell destruction markers (neuron-specific enolase (NSE), S-100 calcium binding protein B (S100B)) were obtained at the end of experiments.
resultsDuring sepsis progression resting cerebral blood flow increased and functionally activated hemodynamic responses decreased in a dose-dependent manner. Whereas 1400W and NE improved blood pressure, only 1400W stabilized resting flow levels. However, both regimens were ineffective on the functionally coupled flow responses and destruction markers were similar between groups.
conclusionsNE and 1400W appeared to be ineffective in mitigating the effects of sepsis on the neurovascular coupling. Other regimens are needed to protect the cerebral microcirculation under septic conditions.
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