Evidence map›Paper›PMID 19709150›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2009

Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study.

J Balani, S L Hyer, D A Rodin, H Shehata

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01273584 (Does Metformin Improve Pregnancy Outcomes), which is not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01273584 phase2 / phase3completedstarted 2010, after this paper: background citation

Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women?

Ran2010Enrolled450Registered outcomes17Posted comparisons0ConditionsObesity, Pregnancy ComplicationsArmsMetformin, Placebo
PMID 14998944PMID 18463376PMID 17434869PMID 10799397other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  16. Interaction between Metformin, Folate and Vitamin BInternational journal of molecular sciences · 2021
    Review
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  18. Predictors of very early postpartum weight loss in women with recent gestational diabetes mellitus.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J BalaniDiabetes Centre, Epsom, Surrey, UK.
S L Hyer
D A Rodin
H Shehata

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo compare maternal and neonatal outcomes in women with gestational diabetes mellitus (GDM) treated with either metformin or insulin.

methodsOne hundred and twenty-seven women with GDM not adequately controlled by dietary measures received metformin 500 mg twice daily initially. The dose was titrated to achieve target blood glucose values. Pregnancy outcomes in the 100 women who remained exclusively on metformin were compared with 100 women with GDM treated with insulin matched for age, weight and ethnicity.

resultsThere were no significant differences in baseline maternal risk factors. Women treated with insulin had significantly greater mean (sem) weight gain from enrolment to term (2.72 +/- 0.4 vs. 0.94 +/- 0.3 kg; P < 0.001). There was no difference between the metformin and insulin groups, respectively, comparing gestational hypertension (6 vs. 7%, P = 0.9), pre-eclampsia (9 vs. 2%, P = 0.06) induction of labour (26 vs. 24%, P = 0.87) or rate of Caesarean section (48 vs. 52%, P = 0.67). No perinatal loss occurred in either group. Neonatal morbidity was improved in the metformin group; prematurity (0 vs. 10%, P < 0.01), neonatal jaundice (8 vs. 30%, P < 0.01) and admission to neonatal unit (6 vs. 19%, P < 0.01). The incidence of macrosomia (birthweight centile > 90) was not significantly different [metformin (14%) vs. insulin (25%); P = 0.07].

conclusionsWomen with GDM treated with metformin and with similar baseline risk factors for adverse pregnancy outcomes had less weight gain and improved neonatal outcomes compared with those treated with insulin. Diabet. Med. 26, 798-802 (2009).

Indexed as

Birth WeightBlood GlucoseBody WeightCase-Control StudiesDiabetes, GestationalFemaleHumansHypoglycemic AgentsInfant, NewbornInsulinMetforminPregnancyPregnancy OutcomeStatistics as TopicTreatment OutcomeBlood GlucoseHypoglycemic AgentsInsulinMetformin

Identifiers

PMID19709150

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.