ReviewCancer science2009
Logical structures extracted from metastasis experiments.
Review in Cancer science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Clinical significance of macrophage heterogeneity in human malignant tumors.Cancer science · 2014Review
- Premetastatic soil and prevention of breast cancer brain metastasis.Neuro-oncology · 2013Article
- Molecular biology of chronic myeloid leukemia.Cancer science · 2012Review
- α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.The Journal of biological chemistry · 2012Article
- Serum amyloid a protein in clinical cancer diagnosis.Pathology oncology research : POR · 2012Article
- Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation.Cellular & molecular immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An inductive argument of metastasis with a metaphor of seed and soil was made by Stephen Paget in 1889. It is commonly held that metastasis is dependent on both the organ from which the primary tumors originate, and the organs to which the tumor cells travel. The assumption is based on the statistical observation of a number of autopsy samples. Here I attempt to establish a theory on the mechanisms of metastasis with experimental evidence. I propose that dysregulation of pro-inflammatory Toll-like receptor 4 signaling, stimulated by its endogenous ligands, establishes pre-metastatic soil. Once specific parameters are established, deductive judgments could be possible to predict to which organ a given tumor metastasizes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.