ArticleMolecular microbiology2009
Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Characterization of a Bacteriocin-like Substance fromVeterinary sciences · 2026Article
- EngineeredBiochemistry · 2026Article
- Molecular Mechanisms of Virulence Regulation inAccounts of chemical research · 2025Article
- Deciphering agr quorum sensing in Staphylococcus aureus: insights and therapeutic prospects.Molecular biology reports · 2024Review
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Significant variability exists in the cytotoxicity of global methicillin-resistantMicrobiology (Reading, England) · 2021Article
- Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives.Antibiotics (Basel, Switzerland) · 2021Review
- Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes.Scientific reports · 2020Article
- Timing Is Everything: Impact of Naturally OccurringJournal of bacteriology · 2019Article
- Identification of a Molecular Latch that Regulates Staphylococcal Virulence.Cell chemical biology · 2019Article
- MroQ Is a Novel Abi-Domain Protein That Influences Virulence Gene Expression inInfection and immunity · 2019Article
- Therapeutic Targeting of theFrontiers in microbiology · 2018Review
- Dynamic Modeling ofFrontiers in microbiology · 2018Article
- Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development.Nature microbiology · 2017Article
- Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation.ACS chemical biology · 2016Article
- Exploration of Modulated Genetic Circuits Governing Virulence Determinants in Staphylococcus aureus.Indian journal of microbiology · 2016Review
- Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.Cell chemical biology · 2016Review
- Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.Expert opinion on investigational drugs · 2015Review
- Influence of the AgrC-AgrA complex on the response time of Staphylococcus aureus quorum sensing.Journal of bacteriology · 2014Article
- Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Virulence in Staphylococcus aureus is largely under control of the accessory gene regulator (agr) quorum-sensing system. The AgrC receptor histidine kinase detects its autoinducing peptide (AIP) ligand and generates an intracellular signal resulting in secretion of virulence factors. Although agr is a well-studied quorum-sensing system, little is known about the mechanism of AgrC activation. By co-immunoprecipitation analysis and intermolecular complementation of receptor mutants, we showed that AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with AIP. Remarkably, addition of specific AIPs to AgrC mutant dimers with only one functional sensor domain caused symmetric activation of either kinase domain despite the sensor asymmetry. Furthermore, mutant dimers involving one constitutive protomer demonstrated ligand-independent activity, irrespective of which protomer was kinase deficient. These results demonstrate that signalling through either individual AgrC protomer causes symmetric activation of both kinase domains. We suggest that such signalling across the dimer interface may be an important mechanism for dimeric quorum-sensing receptors to rapidly elicit a response upon signal detection.
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