ArticleBioconjugate chemistry2009
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Article in Bioconjugate chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Precision chemical engineering of dendrimers for nucleic acid delivery.Nature reviews. Chemistry · 2026Review
- Nanoparticles may influence mast cells gene expression profiles without affecting their degranulation function.Nanomedicine : nanotechnology, biology, and medicine · 2025Article
- Two Decades of Triazine Dendrimers.Molecules (Basel, Switzerland) · 2021Review
- Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties.Bioconjugate chemistry · 2021Article
- Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation.Scientific reports · 2020Article
- Design, synthesis and structure of novel G-2 melamine-based dendrimers incorporating 4-(Beilstein journal of organic chemistry · 2018Article
- Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials.Molecules (Basel, Switzerland) · 2017Review
- Radiolabeled Dendrimers for Nuclear Medicine Applications.Molecules (Basel, Switzerland) · 2017Review
- Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy.Molecules (Basel, Switzerland) · 2017Review
- Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy.Molecules (Basel, Switzerland) · 2015Review
- The key role of the scaffold on the efficiency of dendrimer nanodrugs.Nature communications · 2015Article
- Examination of structure-activity relationship of viologen-based dendrimers as CXCR4 antagonists and gene carriers.Bioconjugate chemistry · 2014Article
- Dendrimers terminated with dichlorotriazine groups provide a route to compositional diversity.Organic letters · 2013Article
- Article
- Dendrimers for siRNA Delivery.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Delivery of siRNA silencing Runx2 using a multifunctional polymer-lipid nanoparticle inhibits osteogenesis in a cell culture model of heterotopic ossification.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Perfectly shaped siRNA delivery.Therapeutic delivery · 2010Article
- Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity.Molecular pharmaceutics · 2010Article
- Divergent synthesis of triazine dendrimers using a trimethylene-dipiperidine linker that increases efficiency, simplifies analysis, and improves product solubility.Tetrahedron letters · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A family of generation 1, 2, and 3 triazine dendrimers differing in their core flexibility was prepared and evaluated for their ability to accomplish gene transfection. Dendrimers and dendriplexes were analyzed by their physicochemical and biological properties such as condensation of DNA, size, surface charge, morphology of dendriplexes, toxic and hemolytic effects, and ultimately transfection efficiency in L929 and MeWo cells. Flexibility of the backbone was found to play an important role with generation 2 dendrimer displaying higher transfection efficiencies than 25 kDa poly(ethylene imine) or SuperFect at a lower cytotoxicity level. This result is surprising, as PAMAM dendrimers require generations 4 or 5 to become effective transfection reagents. The ability to delineate effects of molecular structure and generation of triazine dendrimers with biological properties provides valuable clues for further modifying this promising class of nonviral delivery system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.