ArticleAnalytical chemistry2009
Ultrafast differential ion mobility spectrometry at extreme electric fields coupled to mass spectrometry.
Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Recommendations for reporting ion mobility Mass Spectrometry measurements.Mass spectrometry reviews · 2019Review
- Maximizing Ion Transmission in Differential Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses.Annual review of analytical chemistry (Palo Alto, Calif.) · 2017Review
- Increased Ion Transmission for Differential Ion Mobility Combined with Mass Spectrometry by Implementation of a Flared Inlet Capillary.Journal of the American Society for Mass Spectrometry · 2017Article
- Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming.Analytical chemistry · 2016Article
- Article
- Differential ion mobility separations in up to 100% helium using microchips.Journal of the American Society for Mass Spectrometry · 2014Article
- High-field asymmetric waveform ion mobility spectrometry for mass spectrometry-based proteomics.Expert review of proteomics · 2012Review
- Protein analyses using differential ion mobility microchips with mass spectrometry.Analytical chemistry · 2012Article
- Size, weight and position: ion mobility spectrometry and imaging MS combined.Analytical and bioanalytical chemistry · 2011Review
- High-resolution differential ion mobility separations using planar analyzers at elevated dispersion fields.Analytical chemistry · 2010Article
- A high voltage asymmetric waveform generator for FAIMS.Journal of the American Society for Mass Spectrometry · 2010Article
- High-resolution differential ion mobility separations using helium-rich gases.Analytical chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Microchip-based field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers featuring a grid of 35 mum-wide channels have allowed electric field intensity (E) over 60 kV/cm, or about twice that in previous devices with >0.5 mm gaps. Since the separation speed scales as E4 to E6, these chips filter ions in just approximately 20 micros (or approximately 100-10,000 times faster than "macroscopic" designs), although with reduced resolution. Here we report integration of these chips into electrospray ionization (ESI) mass spectrometry, with ESI coupled to FAIMS via a curtain plate/orifice interface with edgewise ion injection into the gap. Adjusting gas flows in the system permits control of ion residence time in FAIMS, which affects resolving power independently of ion desolvation after the ESI source. The results agree with a priori simulations and scaling rules. Applications illustrated include analyses of amino acids and peptides. Because of limited resolving power, the present FAIMS units are more suitable for distinguishing compound classes than individual species. In particular, peptides separate from many other classes, including PEGs that are commonly encountered in proteomic analyses. In practical analyses with realistic time constraints, the effective separation power of present FAIMS may approach that of "macroscopic" systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.