ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Isolated closed minor-muscle injury of the lower leg did not cause an obvious systemic immune response.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice.Clinical science (London, England : 1979) · 2015Article
- Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study.Clinical orthopaedics and related research · 2013Article
- Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhage*.Critical care medicine · 2012Article
- BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.BMC cell biology · 2011Article
- Orthopedic trauma-induced pulmonary injury in the obese Zucker rat.Microcirculation (New York, N.Y. : 1994) · 2010Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA common consequence in patients with blunt trauma is a deterioration of the immune system. The specific impacts of a frequently occurring isolated soft tissue trauma on the immune response are described. However, the dimension of trauma needed to cause systemic effects has not been definitely elucidated.
methodsMice were traumatized on the lower leg. The extent of soft tissue trauma was quantified by determination of the wet/dry ratio, magnetic resonance imaging (MRI), and serum content of muscle proteins. Five minutes, 3, 24, 36, 48, and 72 h after trauma (a.t.) the ex vivo cytokine-expression of immune-competent cells were measured.
resultsTrauma resulted in an early edema that could be quantified by MRI and wet/dry ration. Release of muscle-specific proteins was detected 5 min a.t. The trauma did not cause significant changes of TNF-alpha response of isolated cells to endotoxin. IL6-response of splenocytes to endotoxin was slightly increased 72 h a.t., while IL6-response of peritoneal macrophages to endotoxin was decreased 36 h a.t.
conclusionWe describe a standardized trauma model for minor soft tissue injury in mice. Systemic effects on the immune system by traumatized lower leg were not found on the level of circulating cytokines or cellular responses to endotoxin.
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