ArticleInternational journal of colorectal disease2010
Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins.
Article in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of universal screening in major lynch-associated tumors: a systematic review of literature.Familial cancer · 2022Pooled it
- Worldwide variation in lynch syndrome screening: case for universal screening in low colorectal cancer prevalence areas.Familial cancer · 2021Pooled it
- Association between heavy metals and colon cancer: an ecological study based on geographical information systems in North-Eastern Iran.BMC cancer · 2021Article
- Correlation of MSH2 exonic deletions and protein downregulation with breast cancer biomarkers and outcome in Pakistani women/patients.Environmental science and pollution research international · 2021Article
- Detection of DNA Mismatch Repair Protein Abnormalities in Sudanese Colorectal Cancer Patients Using Immunohistochemical Methods.Journal of gastrointestinal cancer · 2019Article
- Clinical significance of mismatch repair gene expression in sporadic colorectal cancer.Experimental and therapeutic medicine · 2014Article
- Association of intron and exon polymorphisms of p53 gene in Iranian patients with gastritis.Gastroenterology and hepatology from bed to bench · 2013Article
- Does the prognosis of colorectal cancer vary with tumor site?Gastroenterology and hepatology from bed to bench · 2011Article
- Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico.Familial cancer · 2010Article
- Prognostic classification index in Iranian colorectal cancer patients: Survival tree analysis.South Asian journal of cancerArticle
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Authors and funding
6 authors.
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Abstract
purposeThe aim of the present study was to determine the profile of mismatch repair (MMR) defects in Iranian colorectal cancer patients by using immunohistochemical staining for products of four MMR genes: MLH1, MSH2, PMS2, and MSH6.
methodsTissue samples of 343 patients were immunostained for MLH1, MSH2, PMS2, and MSH6. Clinical and family history and survival data were compared between normal and abnormal staining patterns.
resultsFourteen percent of the patients had abnormal nuclear staining for MMR proteins. MLH1 was absent in four, MLH1/PMS2 in 15, PMS2 in five, MSH2 in 12, and MSH2/MSH6 in 12 patients. These tumors were more proximal, had a nonsignificant better survival, and were more associated with positive family history. Estimation of this study of prevalence of hereditary nonpolyposis colorectal cancer in Iran was 5.5% of the total colorectal cancers.
conclusionsAlong with the recommendations of the National Institute of Cancer, we recommend immunohistochemistry staining for MLH1, MSH2, PMS2, and MSH6 for determining the eligibility of patients for mutation analysis of MMR genes.
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