Evidence map›Paper›PMID 19707702›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010

Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method.

S Dudley-Javoroski, R K Shields

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PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Turning Over the Hourglass.Physical therapy · 2017
    Article
  6. Bone loss at the distal femur and proximal tibia in persons with spinal cord injury: imaging approaches, risk of fracture, and potential treatment options.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Review
  7. Measuring muscle and bone in individuals with neurologic impairment; lessons learned about participant selection and pQCT scan acquisition and analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Review
  8. Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
  9. Review
  10. Bone loss in a new rodent model combining spinal cord injury and cast immobilization.Journal of musculoskeletal & neuronal interactions · 2014
    Article
  11. Article
  12. Article
  13. Bone mineral and stiffness loss at the distal femur and proximal tibia in acute spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Article
  14. Article
  15. Bone mineral loss at the proximal femur in acute spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Article
  16. High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Article
  17. Regional cortical and trabecular bone loss after spinal cord injury.Journal of rehabilitation research and development · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S Dudley-JavoroskiGraduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, 1-252 Medical Education Building, Iowa City, IA 52242-1190, USA.
R K Shields
University of Iowa · US

Funding

Neuro-Musculoskeletal Plasticity after SCIR01NR010285 · NINR · UNIVERSITY OF IOWA · PI SHIELDS, RICHARD K. · 2006 to 2010
$1.6M
Mechanical stress and skeletal plasticity after spinal cord injury in humansR01HD062507 · NICHD · UNIVERSITY OF IOWA · PI SHIELDS, RICHARD K. · 2010 to 2014
$1.5M
NICHD NIH HHS R01 HD062507NINR NIH HHS R01 NR010285NINR NIH HHS R01-NR 010285-05
6 · The paper itself

Abstract

summarySurveillance of femur metaphysis bone mineral density (BMD) decline after spinal cord injury (SCI) may be subject to slice placement error of 2.5%. Adaptations to anti-osteoporosis measures should exceed this potential source of error. Image analysis parameters likewise affect BMD output and should be selected strategically in longitudinal studies.

introductionUnderstanding the longitudinal changes in bone mineral density (BMD) after spinal cord injury (SCI) is important when assessing new interventions. We determined the longitudinal effect of SCI on BMD of the femur metaphysis. To facilitate interpretation of longitudinal outcomes, we (1) determined the BMD difference associated with erroneous peripheral quantitative computed tomography (pQCT) slice placement, and (2) determined the effect of operator-selected pQCT peel algorithms on BMD.

methodspQCT images were obtained from the femur metaphysis (12% of length from distal end) of adult subjects with and without SCI. Slice placement errors were simulated at 3 mm intervals and were processed in two ways (threshold-based vs. concentric peel).

resultsBMD demonstrated a rapid decline over 2 years post-injury. BMD differences attributable to operator-selected peel methods were large (17.3% for subjects with SCI).

conclusionsFemur metaphysis BMD declines after SCI in a manner similar to other anatomic sites. Concentric (percentage-based) peel methods may be most appropriate when special sensitivity is required to detect BMD adaptations. Threshold-based methods may be more appropriate when asymmetric adaptations are observed.

Indexed as

AdolescentAdultBone DensityBone Diseases, MetabolicCross-Sectional StudiesDisease ProgressionFemaleFemurHumansImage Processing, Computer-AssistedLongitudinal StudiesMaleMiddle AgedSpinal Cord InjuriesTomography, X-Ray ComputedYoung Adult

Identifiers

PMID19707702
PMCPMC2875776
OpenAlexW2045912459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.