ArticleBiologics : targets & therapy2008
Clinical use of topical thrombin as a surgical hemostat.
Article in Biologics : targets & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- Effects of intraoperative topical hemostatic agents on chest tube output and thoracic complications following vertebral body tethering.Spine deformity · 2025Article
- Biomaterial-Based and Surgical Approaches to Local Hemostasis in Contemporary Oral Surgery: A Narrative Review.Journal of functional biomaterials · 2025Review
- Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives.Bioactive materials · 2024Article
- TAVAC: comprehensive review of currently available hemostatic products as adjunct to surgical hemostasis.Surgical endoscopy · 2024Review
- Topical hemostatic agents in neurosurgery, a comprehensive review: 15 years update.Neurosurgical review · 2022Review
- Endobronchial blood-patch: A novel technique for a persistent pleural air leak.Respiratory medicine case reports · 2022Article
- Tissue Adhesives: From Research to Clinical Translation.Nano today · 2021Article
- Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.International journal of molecular sciences · 2021Review
- Use of intrapulmonary administration of thrombin in hematological malignancy patients with alveolar haemorrhage: A case series.Medicine · 2020Observational
- Mycotic Aneurysm of the Hepatic Artery: A Case Report and its Management.Journal of clinical imaging science · 2020Article
- Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications.Frontiers in bioengineering and biotechnology · 2020Review
- Combined thrombin and autologous blood for repair of lumbar durotomy.Neurosurgical review · 2016Article
- Improved bleeding scores using Gelfoam(®) Powder with incremental concentrations of bovine thrombin in a swine liver lesion model.Journal of thrombosis and thrombolysis · 2016Article
- Hemostatic effect and distribution of new rhThrombin formulations in rats.Interdisciplinary toxicology · 2014Article
- Surgical Materials: Current Challenges and Nano-enabled Solutions.Nano today · 2014Article
- Clinical applications of surgical adhesives and sealants.Critical reviews in biomedical engineering · 2014Review
- A review article on the diagnosis and treatment of cerebrospinal fluid fistulas and dural tears occurring during spinal surgery.Surgical neurology international · 2013Article
- Bedside bleeding control, review paper and proposed algorithm.The journal of the American College of Clinical Wound Specialists · 2012Review
- Catheter-directed endovascular application of thrombin: Report of 3 cases and review of the literature.Clinical imagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When surgical ligation of bleeding fails, or is not possible, surgeons rely on a number of hemostatic aids, including thrombin. This review discusses the history, pharmacology and clinical application of thrombin as a surgical hemostat. The initial thrombin was bovine in origin, but its use has been complicated by the formation of antibodies that cross react with human coagulation factors. This has been associated with life threatening bleeding and in some circumstances anaphylaxis and death. Human thrombin, isolated from pooled plasma of donors, has been developed in an effort to minimize these risks, but its downside is the potential of transmitting blood-borne pathogens and limited availability. Recently a recombinant thrombin has been developed and approved for use by the FDA. It has the advantage of being minimally antigenic and devoid of the risk if viral transmission. Thrombin is often used in conjunction with other hemostatic aids, including absorbable agents (like gelfoam, collagen, and cellulose), and with fibrinogen in fibrin glues. The last part of this review will discuss these agents in detail, and review their clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.