ArticleBiologics : targets & therapy2008
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia.
Article in Biologics : targets & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Curcumin as adjuvant therapy to improve remission in myeloma patients: A pilot randomized clinical trial.Caspian journal of internal medicine · 2022Article
- B-Cell Disorders and Curcumin.Integrative cancer therapies · 2017Article
- Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia): A Preliminary Clinical Study.Integrative cancer therapies · 2016Article
- Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy.Case reports in hematology · 2015Article
- Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution.Experimental and therapeutic medicine · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather "watchful waiting". Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.
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