ArticleBritish journal of cancer2009
Breastfeeding and early infection in the aetiology of childhood leukaemia in Down syndrome.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of Breastfeeding in Infants With Down Syndrome: A Systematic Review and Meta-Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis.BMC medicine · 2021Pooled it
- A systematic review and meta-analysis of the association between childhood infections and the risk of childhood acute lymphoblastic leukaemia.British journal of cancer · 2018Pooled it
- [Epidemiology of childhood leukemia in Mexico and Latin America: Effects of vulnerability and social justice].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Extremely low-frequency magnetic fields (ELF-MF) and radiofrequency: Risk of childhood CNS tumors in a city with elevated ELF-MF exposure.Environmental research · 2025Article
- Early Infection Incidence and Risk of Acute Leukemia Development Among Mexican Children.Cancers · 2025Article
- Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.Frontiers in oncology · 2024Article
- The best tool for the assessment of developmental disorders in children with down syndrome: comparison of standard and specialized growth charts - cross sectional study.Frontiers in endocrinology · 2022Article
- EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia.BioMed research international · 2014Article
- Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia.British journal of cancer · 2013Article
- Participation in the Supplemental Nutrition Program for Women, Infants and Children (WIC) and breastfeeding: national, regional, and state level analyses.Maternal and child health journal · 2012Article
- Article
- Community based participatory research of breastfeeding disparities in African American women.Infant, child & adolescent nutrition · 2011Article
Corrections and comments
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Authors and funding
20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFor a child to develop acute leukaemia (AL), environmental exposure may not be sufficient: interaction with a susceptibility factor to the disease, such as Down syndrome (DS), may also be necessary. We assessed whether breastfeeding and early infection were associated with the risk of developing AL in children with DS.
methodsChildren with DS in Mexico City, and either with or without AL, were the cases (N=57) and controls (N=218), respectively. Population was divided in children with AL and with acute lymphoblastic leukaemia (ALL) and also in children < or = 6 and >6 years old.
resultsBreastfeeding and early infections showed moderate (but not significant) association for AL, whereas hospitalisation by infection during the first year of life increased the risk: odds ratios (confidence interval 95%) were 0.84 (0.43-1.61), 1.70 (0.82-3.52); and 3.57 (1.59-8.05), respectively. A similar result was obtained when only ALL was analysed.
conclusionWe found that breastfeeding was a protective factor for developing AL and ALL, and during the first year of life, infections requiring hospitalisation were related to a risk for developing the disease in those children with DS >6 years of age. These data do not support the Greaves's hypothesis of early infection being protective for developing ALL.
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