ArticleJournal of experimental botany2009
Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth.
Article in Journal of experimental botany, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Genome-wide identification of HXK gene families in cucumber and watermelon: CsHXK1 and ClHXK6 play key roles in responding to multiple stresses.BMC plant biology · 2026Article
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- Isolation, structure analysis and expression characterization of the Hexokinase gene family in3 Biotech · 2025Article
- GmHXK2 promotes the salt tolerance of soybean seedlings by mediating AsA synthesis, and auxin synthesis and distribution.BMC plant biology · 2024Article
- The ectomycorrhizal fungusFrontiers in microbiology · 2024Article
- OsHXK3 encodes a hexokinase-like protein that positively regulates grain size in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Genome-Wide Survey and Expression Analyses of Hexokinase Family in Poplar (Plants (Basel, Switzerland) · 2022Article
- Heat stress response in Chinese cabbage (PeerJ · 2022Article
- Article
- Genome-Wide Identification and Characterization of Hexokinase Genes in Moso Bamboo (Frontiers in plant science · 2020Article
- Nitrogen Dioxide at Ambient Concentrations Induces Nitration and Degradation of PYR/PYL/RCAR Receptors to Stimulate Plant Growth: A Hypothetical Model.Plants (Basel, Switzerland) · 2019Review
- The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network.International journal of molecular sciences · 2018Review
- Article
- Effects of glucose and ethylene on root hair initiation and elongation in lettuce (Lactuca sativa L.) seedlings.Journal of plant research · 2018Article
- Complex Relationships between Chromatin Accessibility, Sequence Divergence, and Gene Expression in Arabidopsis thaliana.Molecular biology and evolution · 2018Article
- Transitioning to the Next Phase: The Role of Sugar Signaling throughout the Plant Life Cycle.Plant physiology · 2018Review
- Structure, Expression, and Functional Analysis of the Hexokinase Gene Family in Cassava.International journal of molecular sciences · 2017Article
- Hexose kinases and their role in sugar-sensing and plant development.Frontiers in plant science · 2013Article
- Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses.Plant physiology · 2012Article
- Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent analysis of the hexokinase (HXK) gene family from Arabidopsis revealed that three hexokinase-like (HKL) proteins lack catalytic activity, but share about 50% identity with the primary glucose (glc) sensor/transducer protein AtHXK1. Since the AtHKL1 protein is predicted to bind glc, although with a relatively decreased affinity, a reverse genetics approach was used to test whether HKL1 might have a related regulatory function in plant growth. By comparing phenotypes of an HKL1 mutant (hkl1-1), an HXK1 mutant (gin2-1), and transgenic lines that overexpress HKL1 in either wild-type or gin2-1 genetic backgrounds, it is shown that HKL1 is a negative effector of plant growth. Interestingly, phenotypes of HKL1 overexpression lines are generally very similar to those of gin2-1. These are quantified, in part, as reduced seedling sensitivity to high glc concentrations and reduced seedling sensitivity to auxin-induced lateral root formation. However, commonly recognized targets of glc signalling are not apparently altered in any of the HKL1 mutant or transgenic lines. In fact, most, but not all, of the observed phenotypes associated with HKL1 overexpression occur independently of the presence of HXK1 protein. The data indicate that HKL1 mediates cross-talk between glc and other plant hormone response pathways. It is also considered Whether a possibly decreased glc binding affinity of HKL1 could possibly be a feedback mechanism to limit plant growth in the presence of excessive carbohydrate availability is further considered.
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