ArticleEvidence-based complementary and alternative medicine : eCAM2011
Cytotoxic effects of bangladeshi medicinal plant extracts.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Phytomedicinal properties ofIranian journal of basic medical sciences · 2023Review
- The GenusPlants (Basel, Switzerland) · 2022Review
- Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration ofMolecules (Basel, Switzerland) · 2022Article
- Review of phytomedicine, phytochemistry, ethnopharmacology, toxicology, and pharmacological activities of Cymbopogon genus.Frontiers in pharmacology · 2022Review
- Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana.PloS one · 2021Article
- Anticholinesterase Activity of Eight Medicinal Plant Species:Evidence-based complementary and alternative medicine : eCAM · 2021Article
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- Comparative Cytotoxic Activity of Wild Harvested Stems andAdvances in pharmacological and pharmaceutical sciences · 2021Article
- Assessment of the Pharmacological Properties and Phytochemical Profile ofBiomolecules · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer-cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC(50) 1.1-1.6 mg mL(-1)). Seven methanolic extracts from L. indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, X. moluccensis and Aegiceras corniculatum showed low toxicity (IC(50) > 2.5 mg mL(-1)) against mouse fibroblasts but selective cytotoxicity (IC(50) 0.2-2.3 mg mL(-1)) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC(50) 0.01-0.08 mg mL(-1)) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.
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Registered trials
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