Evidence map›Paper›PMID 19706597›Full record

ArticleThe Journal of biological chemistry2009

MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction.

Shimin Dong, Yunhui Cheng, Jian Yang, Jingyuan Li, Xiaojun Liu, Xiaobin Wang, Dong Wang, Thomas J Krall, Ellise S Delphin, Chunxiang Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 1 synthesis or guideline pooled it, 449 citations in OpenAlex.

  1. Pooled it
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  14. Therapeutic Applications of Poly-miRNAs and miRNA Sponges.International journal of molecular sciences · 2025
    Review
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution.

Shimin DongDepartment of Anesthesiology, RNA and Cardiovascular Research Laboratory, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA.
Yunhui Cheng
Jian Yang
Jingyuan Li
Xiaojun Liu
Xiaobin Wang
Dong Wang
Thomas J Krall
Ellise S Delphin
Chunxiang Zhang
Rutgers New Jersey Medical School

Funding

Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole ofR01HL095707 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZHANG, CHUNXIANG · 2010 to 2013
$1.5M
MPO and NO signaling in neointima formationR01HL080133 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZHANG, CHUNXIANG · 2006 to 2010
$1.5M
NHLBI NIH HHS HL080133NHLBI NIH HHS R01 HL080133NHLBI NIH HHS R01 HL095707
6 · The paper itself

Abstract

Several recent reports have suggested that microRNAs (miRNAs) might play critical roles in acute myocardial infarction (AMI). However, the miRNA expression signature in the early phase of AMI has not been identified. In this study, the miRNA expression signature was investigated in rat hearts 6 h after AMI. Compared with the expression signature in the noninfarcted areas, 38 miRNAs were differentially expressed in infarcted areas and 33 miRNAs were aberrantly expressed in the border areas. Remarkably, miR-21 expression was significantly down-regulated in infarcted areas, but was up-regulated in border areas. The down-regulation of miR-21 in the infarcted areas was inhibited by ischemic preconditioning, a known cardiac protective method. Overexpression of miR-21 via adenovirus expressing miR-21 (Ad-miR-21) decreased myocardial infarct size by 29% at 24 h and decreased the dimension of left ventricles at 2 weeks after AMI. Using both gain-of-function and loss-of-function approaches in cultured cardiac myocytes, we identified that miR-21 had a protective effect on ischemia-induced cell apoptosis that was associated with its target gene programmed cell death 4 and activator protein 1 pathway. The protective effect of miR-21 against ischemia-induced cardiac myocyte damage was further confirmed in vivo by decreased cell apoptosis in the border and infarcted areas of the infarcted rat hearts after treatment with Ad-miR-21. The results suggest that miRNAs such as miR-21 may play critical roles in the early phase of AMI.

Indexed as

Gene Expression RegulationAdenoviridaeAnimalsApoptosisCell HypoxiaCells, CulturedMaleMicroRNAsMyocardial InfarctionMyocytes, CardiacRatsRats, Sprague-DawleyTime FactorsTransduction, GeneticMicroRNAs

Identifiers

PMID19706597
PMCPMC2785585
OpenAlexW2080808874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.