ArticleProceedings of the National Academy of Sciences of the United States of America2009
Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Exogenous expression of an allatotropin-related peptide receptor increased the membrane excitability in Aplysia neurons.Molecular brain · 2022Article
- Cyclic AMP response element-binding protein (CREB) transcription factor in astrocytic synaptic communication.Frontiers in synaptic neuroscience · 2022Review
- Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning.Scientific reports · 2020Article
- Serotonergic modulation across sensory modalities.Journal of neurophysiology · 2020Review
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Balanced actions of protein synthesis and degradation in memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka).Scientific reports · 2017Article
- Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.Frontiers in cellular neuroscience · 2017Article
- Nicotine inhibits potassium currents in Aplysia bag cell neurons.Journal of neurophysiology · 2016Article
- Investigating the Potential Signaling Pathways That Regulate Activation of the Novel PKC Downstream of Serotonin in Aplysia.PloS one · 2016Article
- Bidirectional regulation of eEF2 phosphorylation controls synaptic plasticity by decoding neuronal activity patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Modulation of defensive reflex conditioning in snails by serotonin.Frontiers in behavioral neuroscience · 2015Article
- Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation.PloS one · 2015Article
- Aging in Sensory and Motor Neurons Results in Learning Failure in Aplysia californica.PloS one · 2015Article
- Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia.Journal of neurophysiology · 2014Article
- The role of serotonin in memory: interactions with neurotransmitters and downstream signaling.Experimental brain research · 2014Review
- Serotonin and synaptic transmission at invertebrate neuromuscular junctions.Experimental neurobiology · 2012Article
- The rates of protein synthesis and degradation account for the differential response of neurons to spaced and massed training protocols.PLoS computational biology · 2011Article
- A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular identities of these receptors have not yet been identified. We here report the cloning and functional characterization of a 5-HT receptor that is positively coupled to adenylyl cyclase in Aplysia neurons. The cloned receptor, 5-HT(apAC1), stimulates the production of cAMP in HEK293T cells and in Xenopus oocytes. Moreover, the knockdown of 5-HT(apAC1) expression by RNA interference blocked 5-HT-induced cAMP production in Aplysia sensory neurons and blocked synaptic facilitation in nondepressed or partially depressed sensory-to-motor neuron synapses. These data implicate 5-HT(apAC1) as a major modulator of learning related synaptic facilitation in the direct sensory to motor neuron pathway of the gill withdrawal reflex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.