ArticleProceedings of the National Academy of Sciences of the United States of America2009
The XNP remodeler targets dynamic chromatin in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- A genetic screen for regulators of Drosophila histone H1 binding and chromosome structure in vivo.Genetics · 2026Article
- A nociceptor-specific RNAi screen inPeerJ · 2025Article
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- Article
- Reduced histone gene copy number disruptsbioRxiv : the preprint server for biology · 2023Article
- dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Chromosoma · 2017Article
- Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression.The Plant cell · 2017Article
- The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation.Molecular and cellular biology · 2017Article
- Mechanisms of Nucleosome Dynamics In Vivo.Cold Spring Harbor perspectives in medicine · 2016Review
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- Stalled replication forks within heterochromatin require ATRX for protection.Cell death & disease · 2016Article
- Replicating Nucleosomes.Science advances · 2015Article
- ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Release 6 reference sequence of the Drosophila melanogaster genome.Genome research · 2015Article
- Histone variants and epigenetics.Cold Spring Harbor perspectives in biology · 2015Review
- Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.PloS one · 2015Article
- Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs.Genes & development · 2014Article
- Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.PLoS genetics · 2013Article
- ATRX: the case of a peculiar chromatin remodeler.Epigenetics · 2013Review
- Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variant.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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4 authors at 1 institution in 1 country.
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Abstract
Heterochromatic gene silencing results from the establishment of a repressive chromatin structure over reporter genes. Gene silencing is often variegated, implying that chromatin may stochastically switch from repressive to permissive structures as cells divide. To identify remodeling enzymes involved in reorganizing heterochromatin, we tested 11 SNF2-type chromatin remodelers in Drosophila for effects on gene silencing. Overexpression of five remodelers affects gene silencing, and the most potent de-repressor is the alpha-thalassaemia mental retardation syndrome X-linked (ATRX) homolog X-linked nuclear protein (XNP). Although the mammalian ATRX protein localizes to heterochromatin, Drosophila XNP is not a general component of heterochromatin. Instead, XNP localizes to active genes and to a major focus near the heterochromatin of the X chromosome. The XNP focus corresponds to an unusual decondensed satellite DNA block, and both active genes and the XNP focus are sites of ongoing nucleosome replacement. We suggest that the XNP remodeler modulates nucleosome dynamics at its target sites to limit chromatin accessibility. Although XNP at active genes may contribute to gene silencing, we find that a single focus is present across Drosophila species and that perturbation of this site cripples heterochromatic gene silencing. Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.