ArticleProceedings of the National Academy of Sciences of the United States of America2009
Coarse-grained modeling of allosteric regulation in protein receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Sparse networks of conformational fluctuations communicate signals within proteins.bioRxiv : the preprint server for biology · 2025Article
- Predicting allosteric pockets in protein biological assemblages.Bioinformatics (Oxford, England) · 2023Article
- Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsins.The Journal of membrane biology · 2019Review
- Chokepoints in Mechanical Coupling Associated with Allosteric Proteins: The Pyruvate Kinase Example.Biophysical journal · 2019Article
- Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Scientific reports · 2016Article
- AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis.BMC bioinformatics · 2015Article
- Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?Biophysical journal · 2015Article
- Communication over the network of binary switches regulates the activation of A2A adenosine receptor.PLoS computational biology · 2015Article
- The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion.PLoS computational biology · 2014Article
- Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Local packing modulates diversity of iron pathways and cooperative behavior in eukaryotic and prokaryotic ferritins.The Journal of chemical physics · 2014Article
- Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.PLoS biology · 2013Article
- Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulations.Topics in current chemistry · 2013Review
- Exploiting protein flexibility to predict the location of allosteric sites.BMC bioinformatics · 2012Article
- Protein folding pathways and state transitions described by classical equations of motion of an elastic network model.Protein science : a publication of the Protein Society · 2010Article
- Elastic network model of allosteric regulation in protein kinase PDK1.BMC structural biology · 2010Article
- Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery.BMC structural biology · 2010Article
- Cooperative dynamics of proteins unraveled by network models.Wiley interdisciplinary reviews. Computational molecular scienceArticle
- Article
- Global low-frequency motions in protein allostery: CAP as a model system.Biophysical reviewsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Allosteric regulation provides highly specific ligand recognition and signaling by transmembrane protein receptors. Unlike functions of protein molecular machines that rely on large-scale conformational transitions, signal transduction in receptors appears to be mediated by more subtle structural motions that are difficult to identify. We describe a theoretical model for allosteric regulation in receptors that addresses a fundamental riddle of signaling: What are the structural origins of the receptor agonism (specific signaling response to ligand binding)? The model suggests that different signaling pathways in bovine rhodopsin or human beta(2)-adrenergic receptor can be mediated by specific structural motions in the receptors. We discuss implications for understanding the receptor agonism, particularly the recently observed "biased agonism" (selected activation of specific signaling pathways), and for developing rational structure-based drug-design strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.