ArticleProceedings of the National Academy of Sciences of the United States of America2009
Study of free oligosaccharides derived from the bacterial N-glycosylation pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Immunological and pathobiological characteristics of a novel liveFrontiers in veterinary science · 2025Article
- Sweet complexity:Frontiers in cellular and infection microbiology · 2024Review
- The type IX secretion system: Insights into its function and connection to glycosylation inEngineering microbiology · 2022Review
- Spatial Mapping of PlantFrontiers in plant science · 2022Article
- Bacterial glycosylation, it's complicated.Frontiers in molecular biosciences · 2022Review
- Detecting Glucose Fluctuations in theACS chemical biology · 2021Article
- Uncoupling the hydrolysis of lipid-linked oligosaccharide from the oligosaccharyl transfer reaction by point mutations in yeast oligosaccharyltransferase.The Journal of biological chemistry · 2020Article
- Influence of Protein Glycosylation onFrontiers in microbiology · 2020Article
- Proteomics Reveals Multiple Phenotypes Associated withMolecular & cellular proteomics : MCP · 2019Article
- Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide.Scientific reports · 2018Article
- Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Campylobacter jejuni: collective components promoting a successful enteric lifestyle.Nature reviews. Microbiology · 2018Review
- Osmoregulated Periplasmic Glucans.EcoSal Plus · 2017Article
- Engineering the Campylobacter jejuni N-glycan to create an effective chicken vaccine.Scientific reports · 2016Article
- Functional analysis of N-linking oligosaccharyl transferase enzymes encoded by deep-sea vent proteobacteria.Glycobiology · 2016Article
- New insights into the biological role of the osmoregulated periplasmic glucans in pathogenic and symbiotic bacteria.Environmental microbiology reports · 2015Review
- Evaluation of the Role of the opgGH Operon in Yersinia pseudotuberculosis and Its Deletion during the Emergence of Yersinia pestis.Infection and immunity · 2015Article
- A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides.Analytical and bioanalytical chemistry · 2015Article
- Generation and degradation of free asparagine-linked glycans.Cellular and molecular life sciences : CMLS · 2015Review
- Evidence for vital role of endo-β-N-acetylglucosaminidase in the resistance of Arthrobacter protophormiae RKJ100 towards elevated concentrations of o-nitrobenzoate.Extremophiles : life under extreme conditions · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The food-borne pathogen Campylobacter jejuni is one of the leading causes of bacterial gastroenteritis worldwide and the most frequent antecedent in neuropathies such as the Guillain-Barré and Miller Fisher syndromes. C. jejuni was demonstrated to possess an N-linked protein glycosylation pathway that adds a conserved heptasaccharide to >40 periplasmic and membrane proteins. Recently, we showed that C. jejuni also produces free heptasaccharides derived from the N-glycan pathway reminiscent of the free oligosaccharides (fOS) produced by eukaryotes. Herein, we demonstrate that C. jejuni fOS are produced in response to changes in the osmolarity of the environment and bacterial growth phase. We provide evidence showing the conserved WWDYG motif of the oligosaccharyltransferase, PglB, is necessary for fOS release into the periplasm. This report demonstrates that fOS from an N-glycosylation pathway in bacteria are potentially equivalent to osmoregulated periplasmic glucans in other Gram-negative organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.