ArticleProceedings of the National Academy of Sciences of the United States of America2009
Changes in transcript abundance relating to colony collapse disorder in honey bees (Apis mellifera).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 217 citations in OpenAlex.
- Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation.Scientific reports · 2020Pooled it
- A meta-analysis of experiments testing the effects of a neonicotinoid insecticide (imidacloprid) on honey bees.Ecotoxicology (London, England) · 2011Pooled it
- Genome-Wide Profiling of P450 Gene Expression Reveals Caste-Specific and Developmental Patterns inInternational journal of molecular sciences · 2025Article
- Regional patterns and climatic predictors of viruses in honey bee (Apis mellifera) colonies over time.Scientific reports · 2025Article
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- Bee Stressors from an Immunological Perspective and Strategies to Improve Bee Health.Veterinary sciences · 2022Review
- Effects of Insecticides and Microbiological Contaminants onMolecules (Basel, Switzerland) · 2021Review
- Transcriptome-level assessment of the impact of deformed wing virus on honey bee larvae.Scientific reports · 2021Article
- Antiviral Treatment Reveals a Cooperative Pathogenicity of Baculovirus and Iflavirus inJournal of microbiology and biotechnology · 2021Article
- A One-Health Model for Reversing Honeybee (Veterinary sciences · 2020Article
- Unraveling Honey Bee-Veterinary sciences · 2020Article
- Article
- Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.Frontiers in genetics · 2020Article
- Metabolomics-based biomarker discovery for bee health monitoring: A proof of concept study concerning nutritional stress in Bombus terrestris.Scientific reports · 2019Article
- Impact of nutritional stress on the honeybee colony health.Scientific reports · 2019Article
- Varroa destructor parasitism has a greater effect on proteome changes than the deformed wing virus and activates TGF-β signaling pathways.Scientific reports · 2019Article
- Bacterial communities associated with honeybee food stores are correlated with land use.Ecology and evolution · 2018Article
- The virulent, emerging genotype B of Deformed wing virus is closely linked to overwinter honeybee worker loss.Scientific reports · 2017Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colony collapse disorder (CCD) is a mysterious disappearance of honey bees that has beset beekeepers in the United States since late 2006. Pathogens and other environmental stresses, including pesticides, have been linked to CCD, but a causal relationship has not yet been demonstrated. Because the gut acts as a primary interface between the honey bee and its environment as a site of entry for pathogens and toxins, we used whole-genome microarrays to compare gene expression between guts of bees from CCD colonies originating on both the east and west coasts of the United States and guts of bees from healthy colonies sampled before the emergence of CCD. Considerable variation in gene expression was associated with the geographical origin of bees, but a consensus list of 65 transcripts was identified as potential markers for CCD status. Overall, elevated expression of pesticide response genes was not observed. Genes involved in immune response showed no clear trend in expression pattern despite the increased prevalence of viruses and other pathogens in CCD colonies. Microarray analysis revealed unusual ribosomal RNA fragments that were conspicuously more abundant in the guts of CCD bees. The presence of these fragments may be a possible consequence of picorna-like viral infection, including deformed wing virus and Israeli acute paralysis virus, and may be related to arrested translation. Ribosomal fragment abundance and presence of multiple viruses may prove to be useful diagnostic markers for colonies afflicted with CCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.