ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Xenopus as a Model for GI/Pancreas Disease.Current pathobiology reports · 2015Article
- Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors.BMC genomics · 2014Article
- Microarray analysis of Xenopus endoderm expressing Ptf1a.Genesis (New York, N.Y. : 2000) · 2012Article
- Xenopus staufen2 is required for anterior endodermal organ formation.Genesis (New York, N.Y. : 2000) · 2012Article
- Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.Genesis (New York, N.Y. : 2000) · 2012Article
- Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.Developmental biology · 2011Article
- Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic.Neural development · 2011Article
- BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
In mammals, it has been well established that gastrointestinal and pancreatic endocrine cells are specified by a cascade of different transcription factors, but whether these same pathways (or linear relationships) operate in Xenopus is currently unknown. We recently identified the endocrine-specific zinc finger transcription factor insulinoma associated protein 1 (insm1) as a dorsal-enriched gene. We found that insm1 is expressed in the dorsal pancreas as early as NF28, making it one of the earliest markers to be localized to the dorsal pancreas. Through morpholino-mediated knockdown, we demonstrate that insm1 is essential for proper specification of both gastrointestinal and pancreatic endocrine cells. In addition, we place insm1 downstream of ngn3 and upstream of pax6 and neuroD in the endocrine cell transcription factor cascade. These are the first results showing that the endodermal endocrine cell development in Xenopus uses the same transcriptional cascade as in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.