ReviewPediatric cardiology2009
Sildenafil for the treatment of pulmonary hypertension in pediatric patients.
Review in Pediatric cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia.Frontiers in cardiovascular medicine · 2023Article
- Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience.Frontiers in pediatrics · 2023Article
- Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension.Scientific reports · 2022Article
- Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment.Comprehensive Physiology · 2021Article
- Pulmonary Arterial Hypertension in Indonesia: Current Status and Local Application of International Guidelines.Global heart · 2021Review
- Management of Pulmonary Arterial Hypertension in the Pediatric Patient.Current cardiology reports · 2019Review
- Design and rationale of the Fontan Udenafil Exercise Longitudinal (FUEL) trial.American heart journal · 2018Review
- The role of preoperative sildenafil therapy in controlling of postoperative pulmonary hypertension in children with ventricular septal defects.Journal of cardiovascular and thoracic research · 2017Article
- Safety of sildenafil in infants*.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2014Review
- Vascular-targeted therapies for Duchenne muscular dystrophy.Skeletal muscle · 2013Article
- Anaesthetic management of a child with massive extracranial arteriovenous malformation.Journal of anaesthesiology, clinical pharmacology · 2012Article
- Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease.Circulation · 2011Review
- Sildenafil in pediatric pulmonary arterial hypertension.Journal of postgraduate medicineReview
- Physicochemical and Microbiological Stability of the Extemporaneous Sildenafil Citrate Oral Suspension.Scientia pharmaceuticaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase. To date, sildenafil use for pediatric pulmonary hypertension has been characterized for 193 children through 16 studies and 28 case series and reports. The primary efficacy data suggest that sildenafil is beneficial for facilitating the weaning of inhaled nitric oxide in children after cardiac surgery. Compiled safety data suggest that sildenafil is well tolerated among children with idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease. This review summarizes the available data describing the use, safety, and efficacy of sildenafil for children with pulmonary hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.