ArticleChromosoma2010
Partitioning the C. elegans genome by nucleosome modification, occupancy, and positioning.
Article in Chromosoma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- Article
- Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans.Epigenetics & chromatin · 2020Article
- TheGenetics · 2019Review
- Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni.PLoS pathogens · 2018Article
- Repressive Chromatin inGenetics · 2018Review
- Article
- Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing inEpigenetics & chromatin · 2017Article
- StableProceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Genome architecture: from linear organisation of chromatin to the 3D assembly in the nucleus.Chromosoma · 2016Review
- A streamlined tethered chromosome conformation capture protocol.BMC genomics · 2016Article
- Organization of DNA in a bacterial nucleoid.BMC microbiology · 2016Article
- A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans.Epigenetics & chromatin · 2016Article
- Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.Genome research · 2015Article
- The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.PLoS neglected tropical diseases · 2015Article
- Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans.BMC genomics · 2014Article
- High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Article
- C. elegans epigenetic regulation in development and aging.Briefings in functional genomics · 2014Review
- A histone methylation network regulates transgenerational epigenetic memory in C. elegans.Cell reports · 2014Article
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2 authors.
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Abstract
We have characterized two post-translational histone modifications in Caenorhabditis elegans on a genomic scale. Micrococcal nuclease digestion and immunoprecipitation were used to obtain distinct populations of single nucleosome cores, which were analyzed using massively parallel DNA sequencing to obtain positional and coverage maps. Two methylated histone H3 populations were chosen for comparison: H3K4 histone methylation (associated with active chromosomal regions) and H3K9 histone methylation (associated with inactivity). From analysis of the sequence data, we found nucleosome cores with these modifications to be enriched in two distinct partitions of the genome; H3K4 methylation was particularly prevalent in promoter regions of widely expressed genes, while H3K9 methylation was enriched on specific chromosomal arms. For each of the six chromosomes, the highest level of H3K9 methylation corresponds to the pairing center responsible for chromosome alignment during meiosis. Enrichment of H3K9 methylation at pairing centers appears to be an early mark in meiotic chromosome sorting, occurring in the absence of components required for proper pairing of homologous chromosomes. H3K9 methylation shows an intricate pattern within the chromosome arms with a particular anticorrelation to regions that display a strong approximately 10.5 bp periodicity of AA/TT dinucleotides that is known to associate with germline transcription. By contrast to the global features observed with H3K9 methylation, H3K4 methylation profiles were most striking in their local characteristics around promoters, providing a unique promoter-central landmark for 3,903 C. elegans genes and allowing a precise analysis of nucleosome positioning in the context of transcriptional initiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.