ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2010
Expression and localization of aquaporin-1 on the apical membrane of enterocytes in the small intestine of bottlenose dolphins.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative Transcriptome Analysis Reveals Relationship among mRNAs, lncRNAs, and circRNAs of Slow Transit Constipation.BioMed research international · 2021Article
- Expression, Localization, and Effect of High Salt Intake on Electroneutral NaFrontiers in physiology · 2019Article
- Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.General and comparative endocrinology · 2015Article
- Adaptive evolution of the osmoregulation-related genes in cetaceans during secondary aquatic adaptation.BMC evolutionary biology · 2013Article
- Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Article
- Functional characterization of water transport and cellular localization of three aquaporin paralogs in the salmonid intestine.Frontiers in physiology · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small and large intestines are primary sites for water intake in mammals. To reveal how water is absorbed in the intestines of cetaceans, histological and molecular-biological studies were performed on the small intestine of the bottlenose dolphin, Tursiops truncatus. In histological studies using fresh specimens, obvious villi and deep crypts of Lieberkühn, lined by abundant enterocytes with microvilli and goblet cells, were observed in the mucosa. Expressions and immunolocalizations of aquaporin-1 (AQP1), a member of the water-selective channel termed AQP, were also investigated in the intestine. By reverse transcriptional polymerase chain reaction and rapid amplification of cDNA ends using RNA extracted from the dolphins' small intestines, the full length of mRNA for AQP1 was sequenced. The deductive amino acid sequence for an open reading frame showed high homologies with other mammals' AQP1, and water permeability of the protein was certified by cRNA injection to Xenopus oocytes. Immunohistochemistry showed AQP1 distribution on the apical membrane of the enterocytes, especially in the crypts. These data suggest that AQP1 is a channel protein responsible for water absorption in the small intestine of dolphins.
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